{"id":1523,"date":"2023-08-11T08:38:00","date_gmt":"2023-08-11T08:38:00","guid":{"rendered":"https:\/\/www.ahb-lab.com\/?p=1523"},"modified":"2023-08-11T08:38:00","modified_gmt":"2023-08-11T08:38:00","slug":"tgf-%ce%b2-the-cellular-powerhouse-influencing-macrophage-metabolism-and-sepsis-survival","status":"publish","type":"post","link":"https:\/\/www.ahb-lab.com\/zh\/news\/tgf-%ce%b2-the-cellular-powerhouse-influencing-macrophage-metabolism-and-sepsis-survival\/","title":{"rendered":"TGF-\u03b2\uff1a\u5f71\u54cd\u5de8\u566c\u7ec6\u80de\u65b0\u9648\u4ee3\u8c22\u548c\u8d25\u8840\u75c7\u5b58\u6d3b\u7684\u7ec6\u80de\u52a8\u529b\u6e90"},"content":{"rendered":"<p>\u5728\u9519\u7efc\u590d\u6742\u7684\u7ec6\u80de\u751f\u7269\u5b66\u9886\u57df\uff0c\u67d0\u4e9b\u5206\u5b50\u4f1a\u6539\u53d8\u6e38\u620f\u89c4\u5219\uff0c\u5f71\u54cd\u5065\u5eb7\u8f68\u8ff9\u548c\u75be\u75c5\u7ed3\u679c\u3002\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\uff08TGF-\u03b2\uff09\u5c31\u662f\u8fd9\u6837\u4e00\u79cd\u5206\u5b50\uff0c\u5b83\u5728\u5de8\u566c\u7ec6\u80de\u65b0\u9648\u4ee3\u8c22\u4e2d\u7684\u6df1\u8fdc\u4f5c\u7528\u53ca\u5176\u5bf9\u8d25\u8840\u75c7\u5b58\u6d3b\u7684\u6f5c\u5728\u5f71\u54cd\u73b0\u5728\u5907\u53d7\u77a9\u76ee\u3002\u672c\u6587\u5c06\u6df1\u5165\u63a2\u8ba8\u79d1\u5b66\u4fe1\u53f7\uff08Science Signaling\uff09\u5bf9 TGF-\u03b2 \u7684\u5f00\u521b\u6027\u7814\u7a76\uff0c\u9610\u660e\u5176\u5728\u5de8\u566c\u7ec6\u80de\u4e2d\u89e3\u9664\u7cd6\u9175\u89e3\u4e0e\u708e\u75c7\u7684\u8026\u5408\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8fd8\u5c06\u63a2\u8ba8\u6211\u4eec\u7684\u4ea7\u54c1 ICPPX\u00ae \u4e0e TGF-\u03b2 \u4e4b\u95f4\u7684\u534f\u540c\u4f5c\u7528\uff0c\u4ee5\u53ca\u8fd9\u79cd\u5173\u7cfb\u6240\u9884\u793a\u7684\u524d\u666f\u5e7f\u9614\u7684\u6cbb\u7597\u9014\u5f84\u3002<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-1527\" src=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162516@2x.png\" alt=\"TGF-\u03b2\" width=\"1670\" height=\"946\" srcset=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162516@2x.png 1670w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162516@2x-300x170.png 300w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162516@2x-1024x580.png 1024w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162516@2x-768x435.png 768w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162516@2x-1536x870.png 1536w\" sizes=\"(max-width: 1670px) 100vw, 1670px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h2><strong>TGF-\u03b2\uff1a\u7ec6\u80de\u5927\u5e08<\/strong><\/h2>\n<p>TGF-\u03b2 \u662f\u4e00\u79cd\u591a\u529f\u80fd\u7ec6\u80de\u56e0\u5b50\uff0c\u5b83\u662f\u7ec6\u80de\u5927\u5e08\uff0c\u534f\u8c03\u7740\u65e0\u6570\u7684\u8fc7\u7a0b\u3002\u4ece\u7ec6\u80de\u751f\u957f\u548c\u5206\u5316\u5230\u8c03\u8282\u514d\u75ab\u53cd\u5e94\uff0c\u5b83\u7684\u5f71\u54cd\u662f\u5de8\u5927\u800c\u591a\u6837\u7684\u3002\u5728\u514d\u75ab\u7cfb\u7edf\u4e2d\uff0c\u5b83\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\uff0c\u5f15\u5bfc\u7740\u5de8\u566c\u7ec6\u80de--\u4e00\u79cd\u4ee5\u6269\u5927\u6216\u6291\u5236\u708e\u75c7\u53cd\u5e94\u7684\u53cc\u91cd\u6027\u8d28\u800c\u95fb\u540d\u7684\u514d\u75ab\u7ec6\u80de\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u53d7\u4eba\u5c0a\u656c\u7684\u300a\u79d1\u5b66\u4fe1\u53f7\u300b\u6742\u5fd7<\/strong><\/h2>\n<p>\u79d1\u5b66\u4fe1\u53f7\u300b\u662f\u5353\u8d8a\u79d1\u5b66\u7684\u706f\u5854\u3002\u5b83\u4ee5\u4e25\u683c\u7684\u540c\u884c\u8bc4\u5ba1\u7a0b\u5e8f\u800c\u8457\u79f0\uff0c\u5e76\u81f4\u529b\u4e8e\u53d1\u8868\u5f00\u521b\u6027\u7684\u7814\u7a76\u6210\u679c\uff0c\u8fd9\u4f7f\u5b83\u6210\u4e3a\u5168\u7403\u79d1\u5b66\u5bb6\u8ffd\u6367\u7684\u5e73\u53f0\u3002\u6700\u8fd1\u7684 <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scisignal.ade0385\">\u7814\u7a76<\/a>\u672c\u520a\u91cd\u70b9\u62a5\u9053\u7684\u8fd9\u7bc7\u8bba\u6587\uff0c\u662f\u672c\u520a\u81f4\u529b\u4e8e\u63a8\u52a8\u79d1\u5b66\u524d\u6cbf\u7684\u6700\u597d\u8bc1\u660e\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u7406\u89e3 TGF-\u03b2 \u7684\u8303\u5f0f\u8f6c\u53d8<\/strong><\/h2>\n<p>\u79d1\u5b66\u4fe1\u53f7\u300b\uff08Science Signaling\uff09\u6742\u5fd7\u4e0a\u53d1\u8868\u7684\u7814\u7a76\u4e3a TGF-\u03b2 \u5728\u5de8\u566c\u7ec6\u80de\u65b0\u9648\u4ee3\u8c22\u4e2d\u7684\u4f5c\u7528\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5168\u65b0\u7684\u89c6\u89d2\u3002\u4e0e\u4ee5\u5f80\u8ba4\u4e3a\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u7cd6\u9175\u89e3\u4ee3\u8c22\u4f1a\u5bfc\u81f4\u708e\u75c7\u7684\u89c2\u70b9\u76f8\u53cd\uff0c\u8fd9\u9879\u7814\u7a76\u63d0\u51fa\u4e86\u4e00\u79cd\u7ec6\u81f4\u5165\u5fae\u7684\u89c2\u70b9\u3002\u5b83\u63ed\u793a\u4e86\u88ab TGF-\u03b2 \u6fc0\u6d3b\u7684\u5de8\u566c\u7ec6\u80de\u5728\u8fdb\u884c\u7cd6\u9175\u89e3\u4ee3\u8c22\u7684\u540c\u65f6\uff0c\u5176\u708e\u75c7\u53cd\u5e94\u53cd\u800c\u6709\u6240\u51cf\u8f7b\u3002<\/p>\n<p>\u6df1\u5165\u7814\u7a76\u540e\uff0c\u8fd9\u9879\u7814\u7a76\u7ec6\u81f4\u5730\u63ed\u793a\u4e86\u5176\u4e2d\u7684\u5185\u5728\u673a\u5236\u3002TGF-\u03b2 \u80fd\u589e\u5f3a\u7cd6\u9175\u89e3\u9176 PFKL \u7684\u8868\u8fbe\u548c\u6d3b\u6027\uff0c\u4ece\u800c\u4fc3\u8fdb\u7cd6\u9175\u89e3\u3002\u540c\u65f6\uff0c\u5b83\u8fd8\u80fd\u6291\u5236\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u3002\u8fd9\u4e9b\u53cc\u91cd\u6548\u5e94\u5177\u6709\u6df1\u8fdc\u7684\u4e34\u5e8a\u610f\u4e49\uff0c\u5c24\u5176\u662f\u5728\u8d25\u8840\u75c7\u7b49\u60c5\u51b5\u4e0b\u3002\u7814\u7a76\u8868\u660e\uff0cTGF-\u03b2\u9a71\u52a8\u7684\u5de8\u566c\u7ec6\u80de\u7cd6\u9175\u89e3\u589e\u5f3a\u53ef\u80fd\u4e0e\u8840\u6db2\u51dd\u56fa\u5347\u7ea7\u5bfc\u81f4\u7684\u5b58\u6d3b\u7387\u964d\u4f4e\u6709\u5173\uff0c\u800c\u8840\u6db2\u51dd\u56fa\u5347\u7ea7\u662f\u8d25\u8840\u75c7\u7684\u4e00\u79cd\u5371\u9669\u5e76\u53d1\u75c7\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>ICPPX\u00ae\uff1a\u4e0e TGF-\u03b2 \u7684\u9769\u547d\u6027\u8054\u7cfb<\/strong><\/h2>\n<p>ICPPX\u00ae \u662f\u521b\u65b0\u79d1\u5b66\u52aa\u529b\u7684\u89c1\u8bc1\u3002\u5b9e\u9a8c\u5ba4\u7814\u7a76\u8868\u660e\uff0cICPPX\u00ae \u80fd\u5f3a\u70c8\u523a\u6fc0 TGF-\u03b2 \u57fa\u56e0\u7684\u8868\u8fbe\u3002\u5f53\u808c\u8171\u7ec6\u80de\u66b4\u9732\u4e8e ICPPX\u00ae \u65f6\uff0cTGF-\u03b2 \u6d53\u5ea6\u7684\u589e\u52a0\u5448\u5242\u91cf\u4f9d\u8d56\u6027\uff0c\u8fd9\u79cd\u523a\u6fc0\u4f5c\u7528\u5341\u5206\u660e\u663e\u3002\u5206\u5b50\u5206\u6790\uff08\u5982 RT-PCR\uff09\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u8fd9\u4e9b\u53d1\u73b0\uff0c\u5e76\u5f3a\u8c03\u968f\u7740 ICPPX\u00ae \u6d53\u5ea6\u7684\u589e\u52a0\uff0cTGF-\u03b2 \u7684\u8868\u8fbe\u4e5f\u4f1a\u6210\u6b63\u6bd4\u589e\u52a0\u3002<\/p>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-1526\" src=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162301@2x.png\" alt=\"ICPPX\u00ae: A Revolutionary Link to TGF-\u03b2\" width=\"2408\" height=\"1286\" srcset=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162301@2x.png 2408w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162301@2x-300x160.png 300w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162301@2x-1024x547.png 1024w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162301@2x-768x410.png 768w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162301@2x-1536x820.png 1536w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/08\/WX20230811-162301@2x-2048x1094.png 2048w\" sizes=\"(max-width: 2408px) 100vw, 2408px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u66f4\u5e7f\u9614\u7684\u524d\u666f\uff1a\u5f71\u54cd\u548c\u672a\u6765\u65b9\u5411<\/strong><\/h2>\n<p>\u56f4\u7ed5 TGF-\u03b2 \u5728\u5de8\u566c\u7ec6\u80de\u65b0\u9648\u4ee3\u8c22\u4e2d\u7684\u4f5c\u7528\u6240\u63ed\u793a\u7684\u95ee\u9898\u5df2\u7ecf\u8d85\u51fa\u4e86\u5b66\u672f\u754c\u7684\u8303\u56f4\u3002\u5b83\u4eec\u6709\u53ef\u80fd\u91cd\u5851\u8d25\u8840\u75c7\u7b49\u75be\u75c5\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u8fd9\u4e9b\u75be\u75c5\u7684\u6b7b\u4ea1\u7387\u4ee4\u4eba\u751f\u754f\u3002\u968f\u7740\u6211\u4eec\u4e0d\u65ad\u63ed\u5f00 TGF-\u03b2 \u7684\u795e\u79d8\u9762\u7eb1\u53ca\u5176\u4e0e ICPPX\u00ae \u7b49\u4ea7\u54c1\u7684\u534f\u540c\u4f5c\u7528\uff0c\u6211\u4eec\u6b63\u7ad9\u5728\u533b\u5b66\u7a81\u7834\u7684\u8fb9\u7f18\uff0c\u8fd9\u53ef\u80fd\u4f1a\u91cd\u65b0\u5b9a\u4e49\u6cbb\u7597\u6a21\u5f0f\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>TGF-\u03b2 \u4e0e\u73b0\u4ee3\u533b\u5b66\u7684\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n<p>\u8fdb\u5165 21 \u4e16\u7eaa\u540e\uff0cTGF-\u03b2 \u7b49\u5206\u5b50\u5728\u73b0\u4ee3\u533b\u5b66\u4e2d\u7684\u4f5c\u7528\u65e5\u76ca\u660e\u663e\u3002\u5b83\u5728\u7ec6\u80de\u8fc7\u7a0b\u4e2d\u7ef4\u6301\u7684\u590d\u6742\u5e73\u8861\u7a81\u663e\u4e86\u5176\u4f5c\u4e3a\u6cbb\u7597\u9776\u70b9\u7684\u6f5c\u529b\u3002\u79d1\u5b66\u4fe1\u53f7\u300b\uff08Science Signaling\uff09\u6742\u5fd7\u6700\u8fd1\u7684\u7814\u7a76\u7ed3\u679c\u5f88\u6709\u542f\u53d1\u6027\u3002\u8fd9\u4e9b\u53d1\u73b0\u4ee5\u53ca <a href=\"https:\/\/www.ahb-lab.com\/zh\/icppx\/\">ICPPX\u00ae<\/a>\u8be5\u9879\u76ee\u5c55\u793a\u4e86\u57fa\u7840\u79d1\u5b66\u4e0e\u4e34\u5e8a\u5e94\u7528\u7684\u7ed3\u5408\u3002\u8fd9\u79cd\u7ed3\u5408\u4f7f\u4eba\u4eec\u5bf9\u590d\u6742\u7684\u7ec6\u80de\u8fc7\u7a0b\u6709\u4e86\u66f4\u6df1\u5165\u7684\u4e86\u89e3\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u4e3a\u5c06\u8fd9\u4e9b\u89c1\u89e3\u8f6c\u5316\u4e3a\u771f\u6b63\u7684\u5065\u5eb7\u76ca\u5904\u94fa\u5e73\u4e86\u9053\u8def\u3002\u7814\u7a76\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u751f\u6b63\u5728\u643a\u624b\u5408\u4f5c\u3002\u4ed6\u4eec\u7684\u5408\u4f5c\u53ef\u80fd\u4f1a\u5229\u7528 TGF-\u03b2 \u7684\u7279\u6027\u3002\u8fd9\u53ef\u80fd\u4f1a\u4e3a\u5404\u79cd\u75be\u75c5\u5e26\u6765\u7a81\u7834\u6027\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u8fd9\u662f\u91cd\u65b0\u5b9a\u4e49\u4e2a\u6027\u5316\u533b\u7597\u7684\u4e00\u6b65\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u672a\u6765\u4e00\u77a5<\/strong><\/h2>\n<p>\u968f\u7740\u4eba\u4eec\u5bf9 TGF-\u03b2 \u53ca\u5176\u4e0e\u5de8\u566c\u7ec6\u80de\u65b0\u9648\u4ee3\u8c22\u4e4b\u95f4\u9519\u7efc\u590d\u6742\u5173\u7cfb\u7684\u8ba4\u8bc6\u4e0d\u65ad\u52a0\u6df1\uff0c\u533b\u5b66\u754c\u6b63\u7ad9\u5728\u4e00\u4e2a\u6fc0\u52a8\u4eba\u5fc3\u7684\u5341\u5b57\u8def\u53e3\u3002\u5229\u7528\u8fd9\u4e9b\u77e5\u8bc6\u8fdb\u884c\u6cbb\u7597\u5e72\u9884\u7684\u6f5c\u529b\u5de8\u5927\uff0c\u5c24\u5176\u662f\u5728\u8d25\u8840\u75c7\u7b49\u60c5\u51b5\u4e0b\u3002\u50cf ICPPX\u00ae \u8fd9\u6837\u80fd\u8c03\u8282 TGF-\u03b2 \u6c34\u5e73\u7684\u4ea7\u54c1\u53ef\u80fd\u662f\u6253\u5f00\u65b0\u6cbb\u7597\u9014\u5f84\u7684\u94a5\u5319\uff0c\u4e3a\u65e0\u6570\u60a3\u8005\u5e26\u6765\u5e0c\u671b\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u6700\u7ec8\u60f3\u6cd5<\/strong><\/h2>\n<p>\u4e86\u89e3 TGF-\u03b2\u3001TGF-\u03b2 \u5bf9\u5de8\u566c\u7ec6\u80de\u65b0\u9648\u4ee3\u8c22\u7684\u5f71\u54cd\u4ee5\u53ca TGF-\u03b2\u7684\u6f5c\u5728\u6cbb\u7597\u610f\u4e49\uff0c\u662f\u79d1\u5b66\u63a2\u7d22\u5947\u8ff9\u7684\u89c1\u8bc1\u3002\u5f53\u6211\u4eec\u7ad9\u5728\u8fd9\u4e00\u5173\u53e3\uff0c\u501f\u52a9\u524d\u6cbf\u7814\u7a76\u548c ICPPX\u00ae \u7b49\u521b\u65b0\u4ea7\u54c1\uff0c\u533b\u5b66\u79d1\u5b66\u7684\u524d\u666f\u4e00\u7247\u5149\u660e\uff0c\u5145\u6ee1\u673a\u9047\u548c\u5e0c\u671b\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>In the intricate realm of cellular biology, certain molecules emerge as game-changers, influencing health trajectories and disease outcomes. Transforming growth factor-beta (TGF-\u03b2) is one such molecule, now spotlighted for its profound role in macrophage metabolism and its potential implications for sepsis survival. This article delves deep into the groundbreaking research from Science Signaling on TGF-\u03b2, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1529,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":"","gopublish_seo_title":"","gopublish_seo_description":""},"categories":[27,12],"tags":[],"class_list":["post-1523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-icppx","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>TGF-\u03b2: The Cellular Powerhouse Influencing Macrophage Metabolism and Sepsis Survival - AHB Lab<\/title>\n<meta name=\"description\" content=\"Explore TGF-\u03b2 influence on macrophage metabolism, sepsis survival, insights 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