{"id":1736,"date":"2024-01-31T08:08:24","date_gmt":"2024-01-31T08:08:24","guid":{"rendered":"https:\/\/www.ahb-lab.com\/?p=1736"},"modified":"2024-01-31T08:08:24","modified_gmt":"2024-01-31T08:08:24","slug":"why-covid-19-makes-you-sneeze","status":"publish","type":"post","link":"https:\/\/www.ahb-lab.com\/zh\/insights\/why-covid-19-makes-you-sneeze\/","title":{"rendered":"COVID-19 \u4e3a\u4ec0\u4e48\u4f1a\u8ba9\u4eba\u6253\u55b7\u568f"},"content":{"rendered":"<p>\u5bfc\u81f4 COVID-19 \u5168\u7403\u5927\u6d41\u884c\u7684 SARS-CoV-2 \u75c5\u6bd2\u5728\u5176\u611f\u67d3\u8005\u8eab\u4e0a\u8868\u73b0\u51fa\u4e00\u7cfb\u5217\u75c7\u72b6\uff0c\u5176\u4e2d\u6700\u5e38\u89c1\u4f46\u6700\u4ee4\u4eba\u8d39\u89e3\u7684\u75c7\u72b6\u4e4b\u4e00\u5c31\u662f\u5bb9\u6613\u6253\u55b7\u568f\u3002 <a href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2024\/01\/23\/why-does-covid-19-make-you-sneeze\/#:~:text=One%20of%20the%20virus'%20proteins,to%20other%20sneeze%2Dinciting%20viruses.\">\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76<\/a> \u8fd9\u4e00\u53d1\u73b0\u63ed\u793a\u4e86\u75c5\u6bd2\u4e2d\u7684\u4e00\u79cd\u7279\u5b9a\u86cb\u767d\u8d28\u5982\u4f55\u901a\u8fc7\u523a\u6fc0\u547c\u5438\u9053\u795e\u7ecf\u5143\u5f15\u53d1\u6253\u55b7\u568f\u3002\u8fd9\u4e00\u53d1\u73b0\u4e0d\u4ec5\u52a0\u6df1\u4e86\u6211\u4eec\u5bf9 COVID-19 \u7684\u4e86\u89e3\uff0c\u8fd8\u4e3a\u6cbb\u7597\u548c\u9884\u9632\u5f00\u8f9f\u4e86\u65b0\u9014\u5f84\u3002\u8ba9\u6211\u4eec\u4e00\u8d77\u6765\u4e86\u89e3 COVID-19 \u4e3a\u4ec0\u4e48\u4f1a\u8ba9\u60a8\u6253\u55b7\u568f\uff01<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u6253\u55b7\u568f\u53cd\u5c04\uff1a\u4e00\u79cd\u9632\u5fa1\u673a\u5236<\/strong><\/h2>\n<p>\u6253\u55b7\u568f\u662f\u4eba\u4f53\u7684\u4e00\u79cd\u81ea\u7136\u9632\u5fa1\u673a\u5236\uff0c\u65e8\u5728\u5c06\u523a\u6fc0\u7269\u6392\u51fa\u9f3b\u8154\u3002\u5f53\u7070\u5c18\u3001\u82b1\u7c89\u6216\u75c5\u539f\u4f53\u7b49\u5f02\u7269\u8fdb\u5165\u9f3b\u8154\u65f6\uff0c\u4f1a\u523a\u6fc0\u9f3b\u8154\u5185\u654f\u611f\u7684\u7c98\u819c\u3002\u8fd9\u79cd\u523a\u6fc0\u4f1a\u88ab\u611f\u89c9\u795e\u7ecf\u5143\u68c0\u6d4b\u5230\uff0c\u5e76\u5411\u5927\u8111\u53d1\u51fa\u4fe1\u53f7\uff0c\u4ece\u800c\u542f\u52a8\u55b7\u568f\u53cd\u5c04\uff0c\u6709\u6548\u5730\u5c06\u8fd9\u4e9b\u5fae\u7c92\u6392\u51fa\u4f53\u5916\u3002<\/p>\n<p>\u5c31 COVID-19 \u800c\u8a00\uff0c\u6253\u55b7\u568f\u4e5f\u662f\u75c5\u6bd2\u4f20\u64ad\u7684\u4e00\u4e2a\u56e0\u7d20\u3002\u4e00\u4e2a\u55b7\u568f\u53ef\u4ee5\u5411\u7a7a\u6c14\u4e2d\u91ca\u653e\u6570\u5343\u4e2a\u98de\u6cab\uff0c\u6bcf\u4e2a\u98de\u6cab\u90fd\u53ef\u80fd\u5e26\u6709\u75c5\u6bd2\u9897\u7c92\u3002\u8fd9\u4e9b\u98de\u6cab\u53ef\u4ee5\u4f20\u64ad\u76f8\u5f53\u8fdc\u7684\u8ddd\u79bb\uff0c\u5e76\u5728\u7a7a\u6c14\u4e2d\u5f98\u5f8a\uff0c\u589e\u52a0\u611f\u67d3\u4ed6\u4eba\u7684\u98ce\u9669\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>PLpro \u86cb\u767d\u5728 SARS-CoV-2 \u8bf1\u53d1\u7684\u6253\u55b7\u568f\u4e2d\u7684\u4f5c\u7528<\/strong><\/h2>\n<p>\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u7684\u795e\u7ecf\u751f\u7406\u5b66\u5bb6\u6234\u5b89\u5a1c-\u5305\u8482\u65af\u5854\u548c\u5979\u7684\u56e2\u961f\u6700\u8fd1\u5e26\u5934\u8fdb\u884c\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u91cd\u70b9\u7814\u7a76\u4e86 SARS-CoV-2 \u7ed3\u6784\u4e2d\u4e00\u79cd\u540d\u4e3a PLpro \u7684\u75c5\u6bd2\u86cb\u767d\u8d28\u3002PLpro \u5c5e\u4e8e\u88ab\u79f0\u4e3a\u86cb\u767d\u9176\u7684\u9176\u5bb6\u65cf\uff0c\u53c2\u4e0e\u5206\u89e3\u86cb\u767d\u8d28\u3002\u5df2\u77e5\u6765\u81ea\u690d\u7269\u3001\u7ec6\u83cc\u548c\u4eba\u7c7b\u7b49\u4e0d\u540c\u6765\u6e90\u7684\u86cb\u767d\u9176\u80fd\u523a\u6fc0\u611f\u89c9\u795e\u7ecf\u5143\u3002\u7814\u7a76\u4eba\u5458\u63a8\u6d4b\uff0cSARS-CoV-2 \u4e2d\u7684 PLpro \u86cb\u767d\u53ef\u80fd\u5177\u6709\u7c7b\u4f3c\u7684\u4f5c\u7528\u3002<\/p>\n<p>\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e00\u5047\u8bbe\uff0c\u7814\u7a76\u5c0f\u7ec4\u5bf9\u5c0f\u9f20\u8fdb\u884c\u4e86\u5b9e\u9a8c\u3002\u901a\u8fc7\u5c06PLpro\u76f4\u63a5\u5bfc\u5165\u8fd9\u4e9b\u52a8\u7269\u7684\u9f3b\u5b50\uff0c\u4ed6\u4eec\u89c2\u5bdf\u5230\u5b83\u523a\u6fc0\u4e86\u88ab\u79f0\u4e3a\u75db\u89c9\u611f\u53d7\u5668\u7684\u611f\u89c9\u795e\u7ecf\u5143\u4e9a\u7fa4\u3002\u8fd9\u4e9b\u795e\u7ecf\u5143\u901a\u5e38\u4e0e\u75db\u75d2\u611f\u89c9\u6709\u5173\uff0c\u662f\u55b7\u568f\u53cd\u5c04\u4e0d\u53ef\u6216\u7f3a\u7684\u7ec4\u6210\u90e8\u5206\u3002<\/p>\n<h2><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-1740\" style=\"font-size: 16px;\" src=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/01\/WX20240131-155834@2x.png\" alt=\"Sneeze\" width=\"1670\" height=\"988\" srcset=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/01\/WX20240131-155834@2x.png 1670w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/01\/WX20240131-155834@2x-300x177.png 300w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/01\/WX20240131-155834@2x-1024x606.png 1024w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/01\/WX20240131-155834@2x-768x454.png 768w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/01\/WX20240131-155834@2x-1536x909.png 1536w\" sizes=\"(max-width: 1670px) 100vw, 1670px\" \/><\/h2>\n<p>&nbsp;<\/p>\n<h2><strong>\u5b9e\u9a8c\u7ed3\u679c\uff1aPLpro \u4e0e\u6253\u55b7\u568f\u4e4b\u95f4\u5b58\u5728\u76f4\u63a5\u8054\u7cfb<\/strong><\/h2>\n<p>\u5b9e\u9a8c\u7ed3\u679c\u4ee4\u4eba\u5927\u5f00\u773c\u754c\u3002\u4e0e\u63a5\u53d7\u5bf9\u7167\u7269\u8d28\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u63a5\u89e6 PLpro \u7684\u5c0f\u9f20\u5f00\u59cb\u6253\u55b7\u568f\u7684\u901f\u5ea6\u66f4\u5feb\uff0c\u9891\u7387\u66f4\u9ad8\u3002\u8fd9\u79cd\u53cd\u5e94\u51e0\u4e4e\u662f\u7acb\u5373\u53d1\u751f\u7684\uff0c\u6253\u55b7\u568f\u53d1\u751f\u5728\u63a5\u89e6 PLpro \u540e 14 \u79d2\u5de6\u53f3\uff0c\u800c\u5bf9\u7167\u7ec4\u5219\u4e3a 30 \u79d2\u3002\u6253\u55b7\u568f\u9891\u7387\u7684\u660e\u663e\u589e\u52a0\u76f4\u63a5\u5c06 PLpro \u86cb\u767d\u4e0e\u6253\u55b7\u568f\u53cd\u5c04\u7684\u6fc0\u6d3b\u8054\u7cfb\u8d77\u6765\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u8d85\u8d8a COVID-19\uff1a\u5bf9\u5176\u4ed6\u75c5\u6bd2\u7684\u5f71\u54cd<\/strong><\/h2>\n<p>\u8fd9\u9879\u7a81\u7834\u6027\u7814\u7a76\u7684\u610f\u4e49\u8fdc\u4e0d\u6b62 COVID-19\u3002\u7814\u7a76\u8868\u660e\uff0c\u5728\u5176\u4ed6\u75c5\u6bd2\uff08\u5305\u62ec\u5f15\u8d77\u666e\u901a\u611f\u5192\u7684\u75c5\u6bd2\uff09\u4e2d\u53d1\u73b0\u7684\u7c7b\u4f3c\u86cb\u767d\u8d28\u4e5f\u53ef\u80fd\u4ee5\u7c7b\u4f3c\u7684\u65b9\u5f0f\u8bf1\u53d1\u6253\u55b7\u568f\u3002\u8fd9\u8868\u660e\u5b58\u5728\u4e00\u79cd\u66f4\u666e\u904d\u7684\u673a\u5236\uff0c\u5373\u5404\u79cd\u75c5\u6bd2\u90fd\u53ef\u80fd\u4e3b\u52a8\u8bf1\u53d1\u6253\u55b7\u568f\uff0c\u4ece\u800c\u6210\u4e3a\u52a0\u5f3a\u4f20\u64ad\u7684\u4e00\u79cd\u624b\u6bb5\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u6cbb\u7597\u6f5c\u529b\uff1a\u7784\u51c6 PLpro<\/strong><\/h2>\n<p>\u5728 COVID-19 \u4e2d\uff0cPLpro \u88ab\u786e\u8ba4\u4e3a\u6253\u55b7\u568f\u7684\u8bf1\u56e0\uff0c\u8fd9\u4e3a\u6cbb\u7597\u5e72\u9884\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b0\u7684\u9776\u70b9\u3002\u7531\u4e8e PLpro \u5bf9 SARS-CoV-2 \u7684\u590d\u5236\u548c\u4f20\u67d3\u6027\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u6b64\u5b83\u5df2\u6210\u4e3a\u836f\u7269\u5f00\u53d1\u5de5\u4f5c\u7684\u91cd\u70b9\u3002\u4eba\u4eec\u5bf9 PLpro \u5728\u75c7\u72b6\u8868\u8fbe\u4e2d\u7684\u4f5c\u7528\uff0c\u7279\u522b\u662f\u5728\u4fc3\u8fdb\u6253\u55b7\u568f\u548c\u6f5c\u5728\u75c5\u6bd2\u4f20\u64ad\u65b9\u9762\u7684\u4f5c\u7528\u6709\u4e86\u65b0\u7684\u8ba4\u8bc6\uff0c\u8fd9\u8868\u660e\u4ee5 PLpro \u4e3a\u9776\u70b9\u7684\u6291\u5236\u5242\u53ef\u4ee5\u6709\u6548\u5730\u51cf\u5c11\u75c5\u6bd2\u7684\u4f20\u64ad\u548c\u53d7\u611f\u67d3\u8005\u75c7\u72b6\u7684\u4e25\u91cd\u7a0b\u5ea6\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u5e73\u8861\u7684\u6cbb\u7597\u65b9\u6cd5<\/strong><\/h2>\n<p>\u5c3d\u7ba1\u9488\u5bf9 PLpro \u7684\u6cbb\u7597\u524d\u666f\u5e7f\u9614\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u5f3a\u8c03\u9700\u8981\u91c7\u53d6\u4e00\u79cd\u5e73\u8861\u7684\u65b9\u6cd5\u3002\u795e\u7ecf\u514d\u75ab\u5b66\u5bb6\u8d39\u5229\u4f69-\u91cc\u8d1d\u7f57\uff08Felipe Ribeiro\uff09\u6307\u51fa\uff0c\u5173\u952e\u662f\u8981\u786e\u4fdd\u6291\u5236\u8fd9\u4e9b\u673a\u5236\u4e0d\u4f1a\u5bf9\u4eba\u4f53\u7684\u81ea\u7136\u6062\u590d\u8fc7\u7a0b\u4ea7\u751f\u8d1f\u9762\u5f71\u54cd\u3002\u867d\u7136\u51cf\u5c11\u6253\u55b7\u568f\u6709\u53ef\u80fd\u964d\u4f4e\u75c5\u6bd2\u4f20\u64ad\u7387\uff0c\u4f46\u8003\u8651\u5230\u6253\u55b7\u568f\u5728\u5c06\u75c5\u6bd2\u6392\u51fa\u4f53\u5916\u65b9\u9762\u7684\u4f5c\u7528\u4e5f\u5f88\u91cd\u8981\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u7ed3\u8bba<\/strong><\/h2>\n<p>\u53d1\u73b0 SARS-CoV-2 \u4e2d\u7684 PLpro \u86cb\u767d\u5982\u4f55\u8bf1\u53d1\u6253\u55b7\u568f\u6807\u5fd7\u7740\u6211\u4eec\u5bf9 COVID-19 \u7684\u8ba4\u8bc6\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\u3002\u5b83\u51f8\u663e\u4e86\u75c5\u6bd2\u4e0e\u4eba\u4f53\u76f8\u4e92\u4f5c\u7528\u7684\u590d\u6742\u65b9\u5f0f\uff0c\u8d85\u51fa\u4e86\u75c5\u6bd2\u590d\u5236\u548c\u514d\u75ab\u53cd\u5e94\u7684\u4f20\u7edf\u8303\u56f4\u3002\u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u52a0\u6df1\u4e86\u6211\u4eec\u5bf9 COVID-19 \u75c7\u72b6\u7684\u7406\u89e3\uff0c\u8fd8\u4e3a\u5f00\u53d1\u6cbb\u7597\u65b9\u6cd5\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u65b0\u65b9\u5411\uff0c\u4ece\u800c\u51cf\u8f7b\u8fd9\u4e00\u5168\u7403\u5065\u5eb7\u6311\u6218\u7684\u4f20\u64ad\u548c\u5f71\u54cd\u3002\u5728\u6211\u4eec\u7ee7\u7eed\u5e94\u5bf9\u8fd9\u4e00\u590d\u6742\u6d41\u884c\u75c5\u7684\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u6240\u83b7\u5f97\u7684\u6bcf\u4e00\u9879\u77e5\u8bc6\u90fd\u662f\u671d\u7740\u66f4\u6709\u6548\u5730\u6297\u51fb\u75c5\u6bd2\u548c\u4fdd\u62a4\u516c\u4f17\u5065\u5eb7\u7684\u6218\u7565\u8fc8\u51fa\u7684\u4e00\u6b65\u3002<\/p>\n<p>AHB Lab \u7684 HealTide\u00ae \u662f\u4e00\u79cd\u57fa\u4e8e\u80bd\u7684\u5316\u5408\u7269\uff0c\u65e8\u5728\u5bf9\u6297\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u708e\u75c7\u3002\u5b83\u80fd\u6291\u5236 TNF-\u03b1 \u548c IL-1beta \u7ec6\u80de\u56e0\u5b50\uff0c\u6709\u52a9\u4e8e\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u548c\u94f6\u5c51\u75c5\u5173\u8282\u708e\u7b49\u75be\u75c5\u3002\u6b64\u5916\uff0cHealTide\u00ae \u8fd8\u80fd\u9000\u70ed\u6d88\u708e\u3001\u4fdd\u62a4\u548c\u4fee\u590d\u7c98\u819c\uff0c\u662f COX-2 \u6297\u708e\u836f\u548c\u7c7b\u56fa\u9187\u7684\u66ff\u4ee3\u54c1\uff0c\u4e14\u65e0\u526f\u4f5c\u7528\u3002\u5b83\u5bf9\u51cf\u8f7b\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u60a3\u8005\u7684\u75c7\u72b6\u548c\u63d0\u9ad8\u751f\u6d3b\u8d28\u91cf\u7279\u522b\u6709\u6548\u3002AHB \u5b9e\u9a8c\u5ba4\u63d0\u4f9b\u514d\u8d39\u6837\u54c1\uff0c\u8ba9\u60a8\u4eb2\u8eab\u4f53\u9a8c\u5b83\u7684\u76ca\u5904\u3002\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u6211\u4eec\u7684\u00a0<a href=\"https:\/\/www.ahb-lab.com\/zh\/healtide\/\" target=\"_new\" rel=\"noopener\">\u7f51\u7ad9<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>SARS-CoV-2, the virus causing the global pandemic COVID-19, has presented a range of symptoms in those it infects, with one of the most common yet puzzling being the propensity to cause sneezing. A recent study has shed light on this phenomenon, uncovering how a specific protein in the virus triggers sneezing by stimulating neurons in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1743,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[61,13],"tags":[],"class_list":["post-1736","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-healtide","category-insights"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Why COVID-19 Makes You Sneeze - AHB Lab<\/title>\n<meta name=\"description\" content=\"Explore the latest in COVID-19 research: how SARS-CoV-2 triggers you to sneeze, the role of PLpro protein.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ahb-lab.com\/zh\/insights\/why-covid-19-makes-you-sneeze\/\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Why COVID-19 Makes You Sneeze - 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