{"id":1880,"date":"2024-05-29T06:09:15","date_gmt":"2024-05-29T06:09:15","guid":{"rendered":"https:\/\/www.ahb-lab.com\/?p=1880"},"modified":"2024-05-29T06:09:15","modified_gmt":"2024-05-29T06:09:15","slug":"how-faulty-messaging-between-organs-accelerates-aging","status":"publish","type":"post","link":"https:\/\/www.ahb-lab.com\/zh\/news\/how-faulty-messaging-between-organs-accelerates-aging\/","title":{"rendered":"\u5668\u5b98\u95f4\u9519\u8bef\u7684\u4fe1\u606f\u4f20\u9012\u5982\u4f55\u52a0\u901f\u8870\u8001"},"content":{"rendered":"<h2>\u5c3e\u5df4\u7684\u6545\u4e8b\uff1a\u8001\u9f20\u63d0\u4f9b\u7684\u7ebf\u7d22<\/h2>\n<p>\u968f\u7740\u5c0f\u9f20\u5e74\u9f84\u7684\u589e\u957f\uff0c\u5b83\u4eec\u7684\u5c3e\u5df4\u5f80\u5f80\u4f1a\u53d8\u5f97\u50f5\u786c\u548c\u626d\u7ed3\u3002\u7136\u800c\uff0c\u5728\u5723\u8def\u6613\u65af\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u5206\u5b50\u751f\u7269\u5b66\u5bb6\u4eca\u4e95\u771f\u4e00\u90ce\u7684\u5b9e\u9a8c\u5ba4\u91cc\uff0c\u67d0\u4e9b\u7ecf\u8fc7\u57fa\u56e0\u6539\u9020\u7684\u5c0f\u9f20\u5373\u4f7f\u5728\u8870\u8001\u8fc7\u7a0b\u4e2d\u4e5f\u80fd\u4fdd\u6301\u67d4\u8f6f\u548c\u51e0\u4e4e\u7b14\u76f4\u7684\u5c3e\u5df4\u3002\u8fd9\u4e9b\u5c0f\u9f20\u8fd8\u8868\u73b0\u51fa\u5176\u4ed6\u6297\u8870\u8001\u7684\u8ff9\u8c61\uff0c\u6bd4\u5982\u4e0e\u6b63\u5e38\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5b83\u4eec\u66f4\u52a0\u5065\u58ee\uff0c\u5728\u8fd0\u52a8\u8f6e\u4e0a\u82b1\u8d39\u7684\u65f6\u95f4\u66f4\u591a\u3002\u6700\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e9b\u7ecf\u8fc7\u57fa\u56e0\u6539\u9020\u7684\u5c0f\u9f20\u5bff\u547d\u5ef6\u957f\u4e86\u5927\u7ea6 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href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(23)00462-X\">\u5177\u4f53\u6765\u8bf4\uff0c\u968f\u7740\u52a8\u7269\u5e74\u9f84\u7684\u589e\u957f\uff0c\u4e0b\u4e18\u8111\uff08\u5927\u8111\u6df1\u5904\u7684\u63a7\u5236\u4e2d\u5fc3\uff09\u4e2d\u7684\u4e00\u7ec4\u795e\u7ecf\u5143\u4f9d\u7136\u6d3b\u8dc3<\/a>.\u4eca\u4e95\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u8fd9\u4e9b\u795e\u7ecf\u5143\u901a\u8fc7\u4ea4\u611f\u795e\u7ecf\u7cfb\u7edf\u5411\u52a8\u7269\u7684\u8102\u80aa\u50a8\u5b58\u5e93\u53d1\u9001\u4fe1\u53f7\uff0c\u4fc3\u4f7f\u8102\u80aa\u71c3\u70e7\u8102\u8d28\u5e76\u5206\u6ccc\u4e00\u79cd\u540d\u4e3aNAMPT\u7684\u5206\u5b50\u3002\u8fd9\u79cd\u5206\u5b50\u6709\u52a9\u4e8e\u9632\u6b62\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\u4e0e\u8870\u8001\u6709\u5173\u7684\u635f\u4f24\uff0c\u5305\u62ec\u4e0b\u4e18\u8111\u672c\u8eab\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u6c9f\u901a\u4e2d\u65ad<\/h2>\n<p>\u4eca\u4e95\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u968f\u7740\u5c0f\u9f20\u5e74\u9f84\u7684\u589e\u957f\uff0c\u53d1\u9001\u521d\u59cb\u4fe1\u53f7\u7684\u795e\u7ecf\u5143\u901a\u5e38\u4f1a\u8870\u9000\u3002\u8fd9\u5bfc\u81f4\u7f3a\u4e4f\u5bf9\u8102\u80aa\u50a8\u5b58\u7684\u9002\u5f53\u523a\u6fc0\uff0c\u4f7f\u52a8\u7269\u79ef\u805a\u8102\u80aa\uff0c\u53d8\u5f97\u4e45\u5750\u4e0d\u52a8\uff0c\u5e76\u4ea7\u751f\u8f83\u5c11\u7684NAMPT\u3002\u4ece\u6839\u672c\u4e0a\u8bf4\uff0c\u8fd9\u79cd\u6c9f\u901a\u969c\u788d\u52a0\u901f\u4e86\u8eab\u4f53\u673a\u80fd\u7684\u8870\u9000\u3002\u4e0e\u4e4b\u6297\u8861\u4f3c\u4e4e\u80fd\u8ba9\u5c0f\u9f20\u4fdd\u6301\u7cbe\u529b\u5145\u6c9b\u3002<\/p>\n<p>\u4eca\u4e95\u548c\u4ed6\u7684\u7814\u7a76\u5c0f\u7ec4\u662f\u8d8a\u6765\u8d8a\u591a\u63a2\u7d22\u5668\u5b98\u548c\u7ec4\u7ec7\u95f4\u7684\u4ea4\u6d41\u5982\u4f55\u80fd\u5bf9\u6297\u8870\u8001\u7684\u79d1\u5b66\u5bb6\u4e4b\u4e00\u3002\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u9057\u4f20\u5b66\u5bb6\u8bfa\u4f2f\u7279-\u4f69\u91cc\u8499\uff08Norbert Perrimon\uff09\u8ba4\u4e3a\uff0c\u4e86\u89e3\u8fd9\u79cd\u5668\u5b98\u95f4\u7684\u4ea4\u6d41\u5bf9\u4e8e\u7406\u89e3\u8870\u8001\u8fc7\u7a0b\u81f3\u5173\u91cd\u8981\u3002\u7f8e\u56fd\u56fd\u5bb6\u8001\u9f84\u5316\u7814\u7a76\u6240\u751a\u81f3\u5df2\u7ecf\u5f00\u59cb\u7533\u8bf7\u62e8\u6b3e\uff0c\u4ee5\u7814\u7a76\u8fd9\u4e9b\u8054\u7cfb\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u8fdc\u8ddd\u79bb\u4fe1\u53f7\u4f20\u9012\uff1a\u8d85\u8d8a\u6fc0\u7d20<\/h2>\n<p>\u5728\u8fc7\u53bb\u51e0\u5341\u5e74\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u8fdc\u8ddd\u79bb\u4fe1\u53f7\u4f20\u9012\u4e0d\u4ec5\u4ec5\u6d89\u53ca\u4f17\u6240\u5468\u77e5\u7684\u80f0\u817a\u3001\u7532\u72b6\u817a\u3001\u777e\u4e38\u548c\u5375\u5de2\u7b49\u817a\u4f53\u5206\u6ccc\u7684\u6fc0\u7d20\u3002\u73b0\u5728\uff0c\u5927\u591a\u6570\u5668\u5b98\u548c\u7ec4\u7ec7\u4f3c\u4e4e\u90fd\u5728\u76f8\u4e92\u4f20\u9012\u5404\u79cd\u5206\u5b50\u4fe1\u606f\u3002\u4f8b\u5982\uff0c\u8102\u80aa\u4f1a\u53d1\u51fa 100 \u591a\u79cd\u4e0d\u540c\u7684\u4fe1\u53f7\u5206\u5b50\uff0c\u808c\u8089\u4f1a\u53d1\u51fa 600 \u591a\u79cd\u4e0d\u540c\u7684\u4fe1\u53f7\u5206\u5b50\u3002\u5c31\u8fde\u66fe\u88ab\u8ba4\u4e3a\u6c89\u9ed8\u5be1\u8a00\u7684\u9aa8\u9abc\u4e5f\u4f1a\u4e0e\u808c\u8089\u3001\u5927\u8111\u548c\u5176\u4ed6\u5668\u5b98\u8fdb\u884c\u4ea4\u6d41\u3002<\/p>\n<p>\u795e\u7ecf\u7cfb\u7edf\u4e5f\u662f\u8fd9\u4e2a\u4e0d\u65ad\u6269\u5927\u7684\u4fe1\u53f7\u7f51\u7edc\u7684\u4e00\u90e8\u5206\u3002\u725b\u6d25\u5927\u5b66\u7684\u795e\u7ecf\u79d1\u5b66\u5bb6\u5b89\u5a1c-\u591a\u660e\u6208\u65af\uff08Ana Domingos\uff09\u8bf4\uff0c\u7814\u7a76\u4eba\u5458\u6b63\u5728\u7528\u795e\u7ecf\u7cfb\u7edf\u4e2d\u65b0\u53d1\u73b0\u7684\u8054\u7cfb\u91cd\u65b0\u5b9a\u4e49\u89e3\u5256\u5b66\u3002\u4f8b\u5982\uff0c\u80f0\u817a\u708e\uff08\u4e00\u79cd\u80f0\u817a\u708e\u75c7\uff09\u4f1a\u5411\u80ba\u90e8\u53d1\u9001\u708e\u75c7\u4fe1\u53f7\uff0c\u4f7f\u8fd9\u79cd\u75be\u75c5\u6709\u4e00\u534a\u7684\u65f6\u95f4\u662f\u81f4\u547d\u7684\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u7ed8\u5236\u4eba\u4f53\u901a\u4fe1\u7f51\u7edc\u56fe<\/h2>\n<p>\u79d1\u5b66\u5bb6\u4eec\u521a\u521a\u5f00\u59cb\u5bf9\u4eba\u4f53\u7684\u5206\u5b50\u5bf9\u8bdd\u8fdb\u884c\u7f16\u76ee\u3002\u8840\u6db2\u4e2d\u542b\u6709\u4e30\u5bcc\u7684\u5206\u5b50\uff0c\u5b83\u4eec\u53ef\u80fd\u662f\u5668\u5b98\u95f4\u7684\u4fe1\u606f\uff0c\u5f71\u54cd\u7740\u751f\u7406\u6216\u8870\u8001\u3002\u7136\u800c\uff0c\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u7684\u5206\u5b50\u751f\u7269\u5b66\u5bb6\u4f0a\u5229\u4e9a-\u5fb7\u9c81\u5409\u5b81\uff08Ilia Droujinine\uff09\u8bf4\uff0c\u786e\u5b9a\u8fd9\u4e9b\u4fe1\u53f7\u5206\u5b50\u53ca\u5176\u6765\u6e90\u662f\u4e00\u9879\u6311\u6218\u3002<\/p>\n<p>2021 \u5e74\uff0cDroujinine\u3001Perrimon \u53ca\u5176\u540c\u4e8b\u5f00\u53d1\u51fa\u4e00\u79cd\u8bc6\u522b\u6f5c\u5728\u5668\u5b98\u95f4\u4fe1\u53f7\u7684\u6280\u672f\u3002\u4ed6\u4eec\u5bf9\u52a8\u7269\u4f53\u5185\u7684\u4e00\u4e2a\u5668\u5b98\u8fdb\u884c\u4e86\u57fa\u56e0\u6539\u9020\uff0c\u5728\u5373\u5c06\u5206\u6ccc\u7684\u86cb\u767d\u8d28\u4e0a\u9644\u52a0\u751f\u7269\u7d20\u6807\u8bb0\u3002\u8fd9\u4e9b\u88ab\u6807\u8bb0\u7684\u86cb\u767d\u8d28\u5728\u4f53\u5185\u4f20\u64ad\u65f6\uff0c\u4f1a\u643a\u5e26\u4e00\u4e2a\u8868\u660e\u5176\u6765\u6e90\u7684\u5fbd\u7ae0\u3002\u901a\u8fc7\u5728\u679c\u8747\u8eab\u4e0a\u4f7f\u7528\u8fd9\u79cd\u65b9\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4ece\u808c\u8089\u5230\u5934\u90e8\u4ee5\u53ca\u4ece\u8102\u80aa\u4f53\u5230\u817f\u90e8\u7684\u86cb\u767d\u8d28\u30022022 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fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-1884\" src=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/05\/WX20240529-135224@2x.png\" alt=\"Organs\" width=\"790\" height=\"444\" srcset=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/05\/WX20240529-135224@2x.png 790w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/05\/WX20240529-135224@2x-300x169.png 300w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/05\/WX20240529-135224@2x-768x432.png 768w\" sizes=\"(max-width: 790px) 100vw, 790px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h2>\u8001\u9f84\u5316\u4e0e\u6c9f\u901a\u80fd\u529b\u4e0b\u964d<\/h2>\n<p>\u968f\u7740\u5c0f\u9f20\u5e74\u9f84\u7684\u589e\u957f\uff0c\u5927\u8111\u4e0e\u8eab\u4f53\u4e4b\u95f4\u7684\u8054\u7cfb\u4f1a\u51cf\u5f31\u3002\u4eca\u4e95\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u968f\u7740\u4e0b\u4e18\u8111\u4e2d\u7684\u795e\u7ecf\u5143\u53d8\u5f97\u4e0d\u90a3\u4e48\u6d3b\u8dc3\uff0c\u4ea4\u611f\u795e\u7ecf\u4f1a\u4ece\u8102\u80aa\u7ec4\u7ec7\u4e2d\u7f29\u56de\uff0c\u4ece\u800c\u5bfc\u81f4 NAMPT \u7684\u5206\u6ccc\u51cf\u5c11\u3002\u8fd9\u5c31\u5f62\u6210\u4e86\u4e00\u4e2a\u529f\u80fd\u5931\u8c03\u7684\u5faa\u73af\u3002\u4e0b\u4e18\u8111\u6216\u767d\u8272\u8102\u80aa\u7ec4\u7ec7\u4e2d\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u708e\u75c7\u53ef\u80fd\u4f1a\u5f15\u53d1\u8fd9\u79cd\u8870\u9000\u3002<\/p>\n<p>\u6cd5\u5170\u514b\u798f\u6b4c\u5fb7\u5927\u5b66\uff08Goethe University Frankfurt\uff09\u7684\u5fc3\u8840\u7ba1\u751f\u7269\u5b66\u5bb6\u65af\u7279\u51e1\u59ae-\u8fea\u6885\u52d2\uff08Stefanie 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NAMPT \u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u53e6\u4e00\u6761\u524d\u666f\u5e7f\u9614\u7684\u9014\u5f84\u3002NAMPT \u5bf9\u7ef4\u6301\u7ec6\u80de\u5065\u5eb7\u81f3\u5173\u91cd\u8981\uff0c\u5b83\u901a\u8fc7\u7ec6\u80de\u5916\u56ca\u6ce1 (EV) 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<a href=\"https:\/\/www.ahb-lab.com\/zh\/\">AHB Lab<\/a>\u6211\u4eec\u4e0d\u4ec5\u662f\u591a\u80bd\u5408\u6210\u9886\u57df\u7684\u9886\u5bfc\u8005\uff0c\u800c\u4e14\u8fd8\u7ad9\u5728\u751f\u7269\u6280\u672f\u63a2\u7d22\u7684\u6700\u524d\u6cbf\u3002\u6211\u4eec\u7684\u627f\u8bfa\u4e0d\u4ec5\u9650\u4e8e\u591a\u80bd\u751f\u4ea7\uff0c\u8fd8\u5305\u62ec\u63ed\u5f00\u63a8\u52a8\u7a81\u7834\u6027\u5065\u5eb7\u89e3\u51b3\u65b9\u6848\u7684\u5206\u5b50\u5965\u79d8\u3002\u901a\u8fc7\u4e0e\u6700\u65b0\u7684\u79d1\u5b66\u7814\u7a76\uff08\u5305\u62ec\u5bf9\u5668\u5b98\u95f4\u4ea4\u6d41\u548c\u8870\u8001\u7684\u7814\u7a76\uff09\u4fdd\u6301\u4e00\u81f4\uff0cAHB \u5b9e\u9a8c\u5ba4\u81f4\u529b\u4e8e\u63a8\u8fdb\u6211\u4eec\u5bf9\u591a\u80bd\u53ca\u5176\u5728\u9769\u547d\u6027\u751f\u7269\u6280\u672f\u5e94\u7528\u4e2d\u7684\u6f5c\u529b\u7684\u7406\u89e3\u3002\u52a0\u5165\u6211\u4eec\u5427\uff0c\u4e0e\u6211\u4eec\u4e00\u8d77\u5f00\u8f9f\u79d1\u5b66\u65b0\u9053\u8def\uff0c\u4ee5\u6211\u4eec\u5bf9\u5353\u8d8a\u548c\u521b\u65b0\u7684\u575a\u5b9a\u627f\u8bfa\u4e3a\u751f\u7269\u6280\u672f\u7684\u672a\u6765\u505a\u51fa\u8d21\u732e\u3002\u4f5c\u4e3a\u4e00\u5bb6\u591a\u80bd\u751f\u4ea7\u5546\uff0c\u6211\u4eec\u5c06\u62a5\u9053\u6700\u65b0\u7684\u65b0\u95fb\u548c\u8fdb\u5c55\uff0c\u8ba9\u60a8\u4e86\u89e3\u6700\u65b0\u4fe1\u606f\uff0c\u5e76\u4ece\u4e2d\u5f97\u5230\u542f\u53d1\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>The Tale of the Tail: Clues from Mice As mice age, their tails often become stiff and kinked. However, in the lab of molecular biologist Shin-Ichiro Imai at Washington University School of Medicine in St. Louis, certain genetically modified mice maintained limber and nearly straight tails even as they aged. These mice displayed other signs [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1886,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-1880","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How Faulty Messaging Between Organs Accelerates Aging - AHB Lab<\/title>\n<meta name=\"description\" content=\"Faulty organ communication accelerates aging. Discover the latest scientific insights into inter-organ messaging for better longevity.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ahb-lab.com\/zh\/news\/how-faulty-messaging-between-organs-accelerates-aging\/\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How Faulty Messaging Between Organs Accelerates Aging - AHB Lab\" \/>\n<meta property=\"og:description\" content=\"Faulty organ communication accelerates aging. 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