{"id":1961,"date":"2024-06-12T06:35:29","date_gmt":"2024-06-12T06:35:29","guid":{"rendered":"https:\/\/www.ahb-lab.com\/?p=1961"},"modified":"2024-06-12T06:35:29","modified_gmt":"2024-06-12T06:35:29","slug":"biologist-aims-to-solve-cells-biggest-mystery-vaults","status":"publish","type":"post","link":"https:\/\/www.ahb-lab.com\/zh\/news\/biologist-aims-to-solve-cells-biggest-mystery-vaults\/","title":{"rendered":"\u751f\u7269\u5b66\u5bb6\u65e8\u5728\u89e3\u5f00\u7ec6\u80de\u7684\u6700\u5927\u8c1c\u56e2\uff1a\u50a8\u85cf\u5ba4"},"content":{"rendered":"<h2>\u62f1\u9876\u7684\u53d1\u73b0<\/h2>\n<p><a href=\"https:\/\/cnsi.ucla.edu\/leonard-rome-bio\/\">\u4f26\u7eb3\u5fb7-\u7f57\u9a6c<\/a> \u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff08UCLA\uff09\u7684\u535a\u58eb\u751f\u5a04\u6e05\uff08\u97f3\u8bd1\uff09\u5173\u6389\u4e86\u5c0f\u623f\u95f4\u91cc\u7684\u9876\u706f\uff0c\u623f\u95f4\u91cc\u53ea\u5269\u4e0b\u7535\u8111\u663e\u793a\u5668\u548c\u9ad8\u8038\u7684\u7535\u5b50\u663e\u5fae\u955c\u5e95\u90e8\u7684\u8367\u5149\u5c4f\u3002\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff08UCLA\uff09\u7684\u535a\u58eb\u751f Qing Lou \u6307\u7740\u663e\u5fae\u955c\u663e\u793a\u5c4f\u73af\u5f62\u7eff\u8272\u5149\u6655\u4e2d\u7684\u4e00\u4e9b\u5375\u5706\u5f62\u6c61\u70b9\u3002\u5979\u8f6c\u52a8\u8f6c\u76d8\uff0c\u70b9\u51fb\u9f20\u6807\uff0c\u5c31\u80fd\u5c06\u9634\u5f71\u805a\u7126\uff0c\u5e76\u62cd\u4e0b\u7167\u7247\u3002\u51e0\u5341\u4e2a\uff0c\u751a\u81f3\u4e0a\u767e\u4e2a\u5706\u6876\u72b6\u7684\u5fae\u7c92\u7a81\u7136\u5145\u6ee1\u4e86\u7535\u8111\u663e\u793a\u5c4f\u3002<\/p>\n<p>\"\u4ed6\u4eec\u6765\u4e86\uff0c\"\u7f57\u9a6c\u8bf4\uff0c\u5c31\u50cf\u4e00\u4f4d\u81ea\u8c6a\u7684\u7236\u4eb2\u5728\u70ab\u8000\u81ea\u5df1\u7684\u5b69\u5b50\u3002<\/p>\n<p>\u8fd9\u4e9b\u662f\u4ed6\u548c\u4ed6\u5f53\u65f6\u7684\u535a\u58eb\u540e\u5357\u5e0c-\u51ef\u5fb7\u838e\uff08Nancy Kedersha\uff09\u5728 1986 \u5e74\u53d1\u73b0\u7684\u795e\u79d8\u7ec6\u80de\u7ed3\u6784--\u7a79\u7abf\u3002\u6b63\u5982\u4ed6\u548c\u5176\u4ed6\u4eba\u6240\u8bc1\u660e\u7684\u90a3\u6837\uff0c\u7a79\u9686\u662f\u4eba\u7c7b\u7ec6\u80de\u5929\u7136\u5236\u9020\u7684\u6700\u5de8\u5927\u7684\u9897\u7c92\uff0c\u4e5f\u662f\u6700\u4e30\u5bcc\u7684\u9897\u7c92\u4e4b\u4e00\u3002\u6211\u4eec\u7684\u5927\u591a\u6570\u7ec6\u80de\u90fd\u6709\u5927\u7ea6 10,000 \u4e2a\u8fd9\u6837\u7684\u7ed3\u6784\uff0c\u5728\u67d0\u4e9b\u514d\u75ab\u7ec6\u80de\u4e2d\uff0c\u6570\u91cf\u53ef\u80fd\u4f1a\u589e\u52a0\u5230 100,000\u3002\u5b83\u4eec\u7684\u5927\u91cf\u5b58\u5728--\u4ee5\u53ca\u7ec6\u80de\u4e3a\u5236\u9020\u5b83\u4eec\u800c\u5fc5\u987b\u6295\u5165\u7684\u8d44\u6e90--\u8868\u660e\u62f1\u9876\u5177\u6709\u67d0\u79cd\u57fa\u672c\u529f\u80fd\u3002\u4f46\u662f\uff0c\u5c3d\u7ba1\u7f57\u9a6c\u548c\u5176\u4ed6 \"\u62f1\u9876 \"\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u6570\u5341\u5e74\u7684\u7814\u7a76\uff0c\u5b83\u4eec\u7684\u4f5c\u7528\u4ecd\u7136\u4e0d\u5f97\u800c\u77e5\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u62f1\u9876\u4e4b\u8c1c<\/h2>\n<p>\u51e0\u5341\u5e74\u6765\uff0c\u4eba\u4eec\u63d0\u51fa\u4e86\u5404\u79cd\u5047\u8bf4\uff0c\u5305\u62ec\u8d2e\u85cf\u5ba4\u6709\u52a9\u4e8e\u8fd0\u9001\u7ec6\u80de\u5185\u7684\u7269\u8d28\u6216\u6e05\u9664\u6bd2\u7d20\u3002\u7136\u800c\uff0c\u7531\u4e8e\u652f\u6301\u6027\u8bc1\u636e\u672a\u80fd\u5b9e\u73b0\uff0c\u4e00\u4e2a\u53c8\u4e00\u4e2a\u5145\u6ee1\u5e0c\u671b\u7684\u60f3\u6cd5\u88ab\u5426\u5b9a\u6216\u5931\u53bb\u4e86\u52a8\u529b\u3002\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u8d77\u521d\u5bf9\u7f57\u9a6c\u548c\u51ef\u5fb7\u6c99\u7684\u53d1\u73b0\u5145\u6ee1\u70ed\u60c5\uff0c\u4f46\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u4ed6\u4eec\u5bf9\u7a79\u9686\u57fa\u7840\u7814\u7a76\u7684\u8d44\u52a9\u9010\u6e10\u5931\u53bb\u5174\u8da3\u3002<\/p>\n<p>\u7136\u800c\uff0c\u7f57\u9a6c\u4eba\u5bf9\u62f1\u9876\u7684\u75f4\u8ff7\u5e76\u6ca1\u6709\u6d88\u9000\uff0c\u5373\u4f7f\u5176\u4ed6\u7814\u7a76\u4eba\u5458--\u5305\u62ec\u51ef\u5fb7\u6c99--\u4e5f\u5728\u7ee7\u7eed\u524d\u8fdb\u3002\u73b0\u5728\uff0c\u5728\u5176\u4ed6\u8d44\u52a9\u8005\u548c\u5b9e\u9a8c\u5ba4\u7684\u5e2e\u52a9\u4e0b\uff0c\u4ed6\u5df2\u7ecf\u4ece\u7a79\u9876\u7684\u57fa\u7840\u7814\u7a76\u8f6c\u5411\u7814\u7a76\u5982\u4f55\u5728\u533b\u5b66\u548c\u5176\u4ed6\u9886\u57df\u5229\u7528\u7a79\u9876\uff0c\u5c06\u5176\u4f5c\u4e3a\u8f93\u9001\u7597\u6cd5\u7684\u7eb3\u7c73\u7ea7\u5bb9\u5668\u7b49\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u533b\u5b66\u50a8\u85cf\u5ba4<\/h2>\n<p>\u4eca\u5929\u5728\u663e\u5fae\u955c\u4e0b\u89c2\u5bdf\u5230\u7684\u662f\u7528\u8f6c\u57fa\u56e0\u9175\u6bcd\u751f\u4ea7\u7684\uff0c\u5176\u4e2d\u542b\u6709\u4e00\u79cd\u540d\u4e3a CCL21 \u7684\u514d\u75ab\u4fe1\u53f7\u5206\u5b50\uff0c\u8fd9\u79cd\u5206\u5b50\u5177\u6709\u6297\u80bf\u7624\u7684\u6f5c\u529b\u3002Vault Pharma \u662f\u7f57\u9a6c\u5171\u540c\u521b\u529e\u7684\u4e00\u5bb6\u516c\u53f8\uff0c\u5728\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684\u4e00\u4e2a\u5b75\u5316\u5668\u5185\u5de5\u4f5c\uff0c\u8be5\u516c\u53f8\u5e0c\u671b\u5c3d\u5feb\u5728\u4eca\u5e74\u5f00\u59cb\u5bf9\u665a\u671f\u764c\u75c7\u60a3\u8005\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8fd9\u5c06\u6807\u5fd7\u7740\u5408\u6210\u7a79\u9686\u9996\u6b21\u88ab\u6ce8\u5165\u4eba\u4f53\uff0c\u6216\u8bb8\u4e5f\u662f\u8fd9\u4e9b\u795e\u79d8\u7ec6\u80de\u5668\u6210\u4e3a\u7126\u70b9\u7684\u65b0\u5f00\u59cb\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u7f57\u9a6c\u7684\u5386\u7a0b\u4e0e\u6311\u6218<\/h2>\n<p>\u7f57\u9a6c\u73b0\u5e74 75 \u5c81\uff0c\u6709\u4e09\u4e2a\u513f\u5b50\u3002\u4ed6\u7684\u5934\u53d1\u5df2\u7ecf\u82b1\u767d\uff0c\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u80e1\u5b50\u4e5f\u65e9\u5df2\u4e0d\u89c1\u3002\u4ed6\u4e8e 2020 \u5e74\u9000\u4f11\uff0c\u4f46\u73b0\u5728\u6b63\u5f0f\u56de\u5230\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff0c\u6ca1\u6709\u85aa\u6c34\uff0c\u624b\u4e0b\u6709\u4e00\u4e2a\u5b9e\u9a8c\u53f0\u3001\u4e00\u4e2a\u535a\u58eb\u540e\u548c\u4e00\u4e9b\u672c\u79d1\u751f\u3002\u5728\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u52a0\u5dde\u7eb3\u7c73\u7cfb\u7edf\u7814\u7a76\u6240\uff08CNSI\uff09\u7684\u4e00\u95f4\u5c0f\u529e\u516c\u5ba4\u91cc\uff0c\u4ed6\u6574\u5929\u4e0e\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684\u5176\u4ed6\u5b9e\u9a8c\u5ba4\u548c Vault Pharma \u7684\u5c0f\u56e2\u961f\u5c31\u62f1\u9876\u7814\u7a76\u8fdb\u884c\u78cb\u5546\u3002<\/p>\n<p>\u5728\u4e00\u6b21\u5927\u80c6\u7684\u5c1d\u8bd5\u4e2d\uff0c\u4ed6\u548c\u5723\u8def\u6613\u65af\u7684\u4e00\u4e2a\u5b9e\u9a8c\u5ba4\u628a\u75c5\u6bd2\u585e\u8fdb\u4e86\u4fdd\u9669\u5e93\uff0c\u8bd5\u56fe\u89e3\u51b3\u57fa\u56e0\u6cbb\u7597\u4e2d\u7684\u4e00\u4e2a\u91cd\u5927\u95ee\u9898\u3002\u4ed6\u7684\u70ed\u60c5\u5f88\u6709\u611f\u67d3\u529b\u3002\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684\u73af\u5883\u5de5\u7a0b\u5e08\u838e\u8389-\u9a6c\u4ea8\u5fb7\u62c9\uff08Shaily Mahendra\uff09\u51e0\u5e74\u524d\u4e5f\u6210\u4e3a\u4e86\u75c5\u6bd2\u5e93\u7684\u7688\u4f9d\u8005\uff0c\u5979\u5728\u5408\u6210\u75c5\u6bd2\u5e93\u4e2d\u88c5\u5165\u4e86\u7528\u4e8e\u5206\u89e3\u5730\u4e0b\u6c34\u6c61\u67d3\u7269\u7684\u9176\u3002\u73b0\u5728\uff0c\u5979\u548c\u7f57\u9a6c\u5f97\u5230\u4e86\u57fa\u91d1\u4f1a\u548c\u8054\u90a6\u673a\u6784\u7684\u652f\u6301\uff0c\u7814\u7a76\u5c01\u88c5\u662f\u5426\u6709\u52a9\u4e8e\u9176\u5728\u9646\u5730\u6216\u6c34\u4e2d\u6563\u5e03\u65f6\u66f4\u597d\u5730\u53d1\u6325\u4f5c\u7528\uff0c\u5e76\u6301\u7eed\u66f4\u957f\u65f6\u95f4\u3002<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-1964\" src=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/06\/WX20240612-142427@2x.png\" alt=\"vault\" width=\"792\" height=\"610\" srcset=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/06\/WX20240612-142427@2x.png 792w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/06\/WX20240612-142427@2x-300x231.png 300w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/06\/WX20240612-142427@2x-768x592.png 768w\" sizes=\"(max-width: 792px) 100vw, 792px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h2>\u91d1\u5e93\u7684\u8d77\u6e90<\/h2>\n<p>\u7f57\u9a6c\u5728\u672c\u79d1\u9636\u6bb5\u66fe\u5c31\u4e3b\u4fee\u827a\u672f\u8fd8\u662f\u5316\u5b66\u8fdb\u884c\u8fc7\u4e89\u8bba\uff0c\u5f53\u65f6\u4ed6\u7684\u827a\u672f\u8001\u5e08\u6e29\u548c\u5730\u5efa\u8bae\u4ed6\u9009\u62e9\u540e\u8005\u66f4\u4e3a\u5b9e\u7528\u3002\u540e\u6765\uff0c\u4ed6\u8f6c\u5b66\u5230\u751f\u7269\u5316\u5b66\u4e13\u4e1a\uff0c\u8fd9\u5728\u5f53\u65f6\u6d89\u53ca\u5230\u5f88\u591a\u7ec6\u80de\u751f\u7269\u5b66\u77e5\u8bc6\u3002\u4ed6\u5728\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684\u7b2c\u4e00\u4e2a\u5b9e\u9a8c\u5ba4\u4e3b\u8981\u7814\u7a76\u4e00\u79cd\u7ec6\u80de\u7ed3\u6784\uff1a\u88ab\u79f0\u4e3a \"\u51dd\u96c6\u7d20\u5305\u88ab\u56ca\u6ce1 \"\u7684\u8102\u8d28\u7403\u4f53\u3002\u5b83\u4eec\u5c06\u9176\u8fd0\u9001\u5230\u79f0\u4e3a\u6eb6\u9176\u4f53\u7684\u7ec6\u80de\u5668\u4e2d\uff0c\u5e2e\u52a9\u5206\u89e3\u5176\u4ed6\u5206\u5b50\u3002<\/p>\n<p>1983 \u5e74\uff0c\u51ef\u5fb7\u838e\u52a0\u5165\u4e86\u7f57\u9a6c\u7684\u7814\u7a76\u5c0f\u7ec4\uff0c\u5f53\u65f6\u5979\u521a\u4ece\u7f57\u683c\u65af\u5927\u5b66\u7684\u535a\u58eb\u8bfe\u7a0b\u6bd5\u4e1a\uff0c\u4f46\u4e4b\u524d\u5df2\u7ecf\u505a\u4e86\u591a\u5e74\u7684\u5b9e\u9a8c\u5ba4\u6280\u672f\u5458\u3002\u4e24\u4eba\u5e74\u9f84\u76f8\u4eff\uff0c\u5f88\u5feb\u5c31\u5efa\u7acb\u4e86\u9ed8\u5951\u3002\u7f57\u9a6c\u6307\u6d3e\u5979\u7684\u4efb\u52a1\u662f\u6bd4\u8f83\u8fdb\u5165\u6eb6\u9176\u4f53\u7684\u56ca\u6ce1\u548c\u79bb\u5f00\u6eb6\u9176\u4f53\u7684\u56ca\u6ce1\u3002\u5f53\u5979\u7528\u51dd\u80f6\u6839\u636e\u7535\u8377\u5206\u79bb\u4e0d\u540c\u79cd\u7c7b\u7684\u56ca\u6ce1\u65f6\uff0c\u610f\u5916\u5730\u53d1\u73b0\u591a\u4e86\u4e00\u6761\u5e26\u5b50\uff0c\u8868\u660e\u662f\u53e6\u4e00\u79cd\u7ed3\u6784\u3002\u7531\u4e8e\u65e0\u6cd5\u8bc6\u522b\uff0c\u5979\u5c1d\u8bd5\u7528\u91cd\u91d1\u5c5e\u67d3\u8272\u5242\u6d78\u6ce1\u7ec6\u80de\u5236\u5907\u7269\uff0c\u7136\u540e\u518d\u7528\u7535\u5b50\u663e\u5fae\u955c\u89c2\u5bdf\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u4e3a\u4fdd\u9669\u5e93\u547d\u540d<\/h2>\n<p>\u5c31\u50cf\u6c6a\u6d0b\u4e2d\u7684\u5c9b\u5c7f\uff0c\u767d\u8272\u7684\u5375\u5f62\u8f6e\u5ed3\u51fa\u73b0\u5728\u4e00\u6ee9\u6c61\u6e0d\u7684\u80cc\u666f\u4e2d\u3002\u67d3\u8272\u5242\u4ece\u8fd9\u4e9b\u7ed3\u6784\u4e0a\u6eda\u843d\uff0c\u663e\u793a\u51fa\u5b83\u4eec\u7684\u5f62\u72b6\u3002\u540e\u7eed\u5b9e\u9a8c\u53d1\u73b0\uff0c\u8bb8\u591a\u7ec6\u80de\u6210\u5206\u4e2d\u5e38\u89c1\u7684\u8102\u8d28\u819c\u7684\u4f20\u7edf\u67d3\u8272\u5242\u65e0\u6cd5\u4e0e\u7a79\u7abf\u7684\u7eaf\u86cb\u767d\u8d28\u5916\u58f3\u7ed3\u5408\uff0c\u8fd9\u4e5f\u662f\u5b83\u4eec\u957f\u671f\u4ee5\u6765\u672a\u88ab\u53d1\u73b0\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/p>\n<p>\u5b9e\u9a8c\u5ba4\u4e3e\u884c\u4e86\u4e00\u6b21\u7ade\u8d5b\uff0c\u4e3a\u8fd9\u4e9b\u5f62\u72b6\u50cf\u7f8e\u56fd\u5c0f\u8db3\u7403\u7684\u4e0d\u660e\u7ec6\u80de\u7269\u4f53\u547d\u540d\u3002\u4e00\u4e9b\u4eba\u5efa\u8bae\u7528\u624b\u69b4\u5f39\u6216\u8986\u76c6\u5b50\u3002Romesomes\u662f\u6700\u53d7\u6b22\u8fce\u7684\u9009\u62e9\uff0cRome\u5f88\u5feb\u7528Kedershacules\u53cd\u9a73\u4e86\u8fd9\u4e2a\u9009\u62e9\u3002\u4f46\u5f53\u535a\u58eb\u540e\u8bf4\u5979\u89c9\u5f97\u8fd9\u4e9b\u7269\u4f53\u7684\u8f6e\u5ed3\u5f88\u50cf\u5927\u6559\u5802\u7684\u62f1\u5f62\u5929\u82b1\u677f\u65f6\uff0c\u8fd9\u4e2a\u540d\u5b57\u5c31\u88ab\u8bb0\u4f4f\u4e86\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u672a\u89e3\u4e4b\u8c1c<\/h2>\n<p>\u591a\u5e74\u6765\uff0c\u7f57\u9a6c\u7684\u5b9e\u9a8c\u5ba4\u548c\u5176\u4ed6\u4e00\u4e9b\u5b9e\u9a8c\u5ba4\u5df2\u7ecf\u5efa\u7acb\u4e86\u66f4\u8be6\u7ec6\u7684\u62f1\u9876\u56fe\u3002\u62f1\u9876\u5927\u7ea6\u6bd4\u8db3\u7403\u5c0f 1000 \u4e07\u500d\uff0c\u4f46\u5bf9\u7ec6\u80de\u6765\u8bf4\u4ecd\u7136\u5f88\u5927--\u5927\u7ea6\u662f\u5c06 RNA \u7ffb\u8bd1\u6210\u86cb\u767d\u8d28\u7684\u6838\u7cd6\u4f53\u8d28\u91cf\u7684\u4e09\u500d\u3002\u6bcf\u4e2a\u6838\u7cd6\u4f53\u7531 78 \u4efd\u62c9\u957f\u7684\u4e3b\u8981\u62f1\u9876\u86cb\u767d\uff08MVP\uff09\u7ec4\u6210\uff0c\u6392\u5217\u65b9\u5f0f\u6709\u70b9\u50cf\u6728\u6876\u4e2d\u7684\u6728\u6761\u3002\u91cc\u9762\u662f\u7531\u53e6\u5916\u4e24\u79cd\u86cb\u767d\u8d28\u548c\u77ed\u62f1\u9876 RNA\uff08vRNA\uff09\u7ec4\u6210\u7684\u56e2\u5757\u3002<\/p>\n<p>\u8fd9\u4e9b\u62f1\u9876\u6210\u5206\u7684\u57fa\u56e0\u5b58\u5728\u4e8e\u5404\u79cd\u771f\u6838\u751f\u7269--\u90a3\u4e9b\u5c06 DNA \u5305\u5728\u7ec6\u80de\u6838\u4e2d\u5e76\u5177\u6709\u5176\u4ed6\u7ec6\u80de\u7279\u5f81\u7684\u751f\u7269--\u4f46\u6606\u866b\u3001\u690d\u7269\u548c\u771f\u83cc\u662f\u660e\u663e\u7684\u4f8b\u5916\u3002\u7ec6\u83cc\u4f3c\u4e4e\u4e5f\u7f3a\u4e4f\u8fd9\u79cd\u7ed3\u6784\u30022013 \u5e74\u7684\u4e00\u9879\u7814\u7a76\u4e3a\u6240\u6709\u5df2\u77e5\u5177\u6709\u7a79\u9686\u7684\u751f\u7269\u6784\u5efa\u4e86\u4e00\u68f5\u5bb6\u8c31\u6811\uff0c\u5e76\u5f97\u51fa\u7ed3\u8bba\u8ba4\u4e3a\uff0c\u8fd9\u4e9b\u7a79\u9686\u53ef\u4ee5\u8ffd\u6eaf\u5230\u6570\u5341\u4ebf\u5e74\u524d\u5047\u5b9a\u7684\u771f\u6838\u751f\u7269\u6700\u540e\u4e00\u4e2a\u5171\u540c\u7956\u5148\u3002\u968f\u7740\u8fdb\u5316\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u4e00\u4e9b\u4e16\u7cfb\u663e\u7136\u5931\u53bb\u4e86\u5b83\u4eec\u3002<\/p>\n<p>\u6839\u636e\u5b83\u4eec\u7684\u6876\u72b6\u5f62\u72b6\uff0c\u7f57\u9a6c\u6700\u521d\u6000\u7591\u62f1\u9876\u662f\u5426\u5728\u7ec6\u80de\u5185\u62fe\u53d6\u548c\u91ca\u653e\u8d27\u7269\uff0c\u6216\u8bb8\u4ece\u7ec6\u80de\u6838\u5230\u5176\u4ed6\u4f4d\u7f6e\u7684\u8def\u7ebf\u3002\u62f1\u9876\u4f3c\u4e4e\u805a\u96c6\u5728\u88ab\u79f0\u4e3a\u6838\u5b54\u590d\u5408\u4f53\u7684\u7f51\u5173\u5468\u56f4\uff0c\u53ef\u80fd\u4e0e\u5b83\u4eec\u7684\u5f00\u53e3\u76f8\u543b\u5408\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u764c\u75c7\u7814\u7a76\u50a8\u85cf\u5ba4<\/h2>\n<p>1996 \u5e74\uff0c\u6b27\u6d32\u764c\u75c7\u7814\u7a76\u4eba\u5458\u5728\u7814\u7a76\u4e00\u79cd\u5728\u8010\u836f\u6027\u764c\u7ec6\u80de\u4e2d\u5f02\u5e38\u4e30\u5bcc\u7684\u86cb\u767d\u8d28\u65f6\uff0c\u514b\u9686\u4e86\u8be5\u57fa\u56e0\uff0c\u5e76\u53d1\u73b0\u5b83\u4e0e\u8001\u9f20\u4f53\u5185\u7684 MVP \u57fa\u56e0\u76f8\u4f3c\u3002\u7814\u7a76\u5c0f\u7ec4\u4e0e\u7f57\u9a6c\u5b9e\u9a8c\u5ba4\u7684\u74e6\u83b1\u4e3d-\u57fa\u514b\u970d\u8d39\u5c14\u5408\u4f5c\uff0c\u53d1\u73b0\u8010\u836f\u764c\u7ec6\u80de\u6bd4\u975e\u8010\u836f\u764c\u7ec6\u80de\u4ea7\u751f\u66f4\u591a\u7684\u7a79\u9686\uff0c\u8fd9\u8868\u660e\u8fd9\u79cd\u7ed3\u6784\u53ef\u4ee5\u5c01\u5b58\u6216\u6392\u51fa\u5316\u7597\u836f\u7269\u3002\u4f46\u4ee4\u7814\u7a76\u4eba\u5458\u611f\u5230\u6cae\u4e27\u7684\u662f\uff0c\u963b\u6b62\u7a79\u7abf\u6216 MVP \u7684\u4ea7\u751f\u5e76\u6ca1\u6709\u4f7f\u7ec6\u80de\u66f4\u5bb9\u6613\u53d7\u5230\u836f\u7269\u7684\u5f71\u54cd\u3002<\/p>\n<p>2002 \u5e74\uff0c\u8377\u5170\u7684\u4e00\u4e2a\u7814\u7a76\u5c0f\u7ec4\u7981\u7528\u4e86\u4e00\u7cfb\u5217\u5c0f\u9f20\u7684 MVP \u57fa\u56e0\uff0c\u4ece\u800c\u63ed\u5f00\u4e86\u7a79\u9686\u7684\u795e\u79d8\u9762\u7eb1\u3002\u8fd9\u4e9b\u556e\u9f7f\u7c7b\u52a8\u7269\u6ca1\u6709\u62f1\u9876\uff0c\u4f46\u53d1\u80b2\u6b63\u5e38\uff0c\u770b\u8d77\u6765\u5f88\u5065\u5eb7\uff0c\u7e41\u6b96\u80fd\u529b\u5f3a\uff0c\u5bff\u547d\u4e0e\u666e\u901a\u5c0f\u9f20\u4e00\u6837\u957f\u3002\u968f\u540e\u53c8\u6572\u9664\u4e86\u53e6\u5916\u4e24\u4e2a\u7a79\u9876\u86cb\u767d\u57fa\u56e0\uff0c\u5c0f\u9f20\u4e5f\u5b89\u7136\u65e0\u6059\u3002\u6700\u8fd1\uff0c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684\u7ef4\u8fea\u52a0\u5c14\u56e2\u961f\u53c8\u7981\u7528\u4e86\u5c0f\u9f20\u7684 vRNA \u57fa\u56e0\uff0c\u7ed3\u679c\u53d1\u73b0\u8fd9\u4e9b\u556e\u9f7f\u52a8\u7269\u4e5f\u6ca1\u6709\u53d1\u751f\u91cd\u5927\u53d8\u5316\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u4fdd\u9669\u5e93\u7814\u7a76\u7684\u672a\u6765<\/h2>\n<p>\u5c3d\u7ba1\u8fd9\u4e9b\u53d1\u73b0\u4ee4\u4eba\u8d39\u89e3\uff0c\u4f46\u7f57\u9a6c\u7684\u5b9e\u9a8c\u5ba4\u4ecd\u5728\u7ee7\u7eed\u63a2\u7d22\u62f1\u9876\u7684\u6f5c\u529b\u3002\u76ee\u524d\uff0c\u4ed6\u4eec\u6b63\u5728\u7814\u7a76\u5229\u7528\u62f1\u9876\u8f93\u9001\u57fa\u56e0\u7597\u6cd5\u548c\u75ab\u82d7\u3002Vault Pharma \u516c\u53f8\u867d\u7136\u9762\u4e34\u8d44\u91d1\u6311\u6218\uff0c\u4f46 CCL21 \u764c\u75c7\u7597\u6cd5\u7684\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u5373\u5c06\u5f00\u59cb\u3002<\/p>\n<p>\u7f57\u9a6c\u4f9d\u7136\u4e50\u89c2\u3002\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\uff0c\u4ed6\u63a8\u51fa\u4e86\u4e00\u7cfb\u5217\u5728\u7ebf\u89c6\u9891\uff0c\u4ee5\u6fc0\u52b1\u65b0\u4e00\u4ee3\u7684\u8df3\u4f1e\u8fd0\u52a8\u5458\u3002\u5728\u4ed6\u7684YouTube\u9891\u9053 \"The Vault Guy \"\u4e0a\uff0c\u7f57\u9a6c\u5c06\u7b11\u8bdd\u548c\u5361\u901a\u52a8\u753b\u4e0e\u6709\u5173\u79d1\u5b66\u65b9\u6cd5\u3001\u8d44\u91d1\u548c\u51fa\u7248\u7684\u4e25\u8083\u8ba8\u8bba\u7ed3\u5408\u5728\u4e00\u8d77\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd9\u4e2a\u7cfb\u5217\u7684\u8ba2\u9605\u8005\u8fd8\u4e0d\u5230 100 \u4eba\uff0c\u5e76\u6ca1\u6709\u8fbe\u5230\u75c5\u6bd2\u5f0f\u4f20\u64ad\u7684\u7a0b\u5ea6\u3002\u4f46\u662f\uff0c\u67d0\u4e9b\u89c2\u4f17\u53ef\u80fd\u5c31\u662f\u6700\u7ec8\u89e3\u5f00\u8fd9\u4e2a\u5927\u8c1c\u56e2\u7684\u4eba\u3002<\/p>\n<p>\"\u4e50\u89c2\u7684\u6211\u8ba4\u4e3a\uff0c\u5728\u6211\u6b7b\u4e4b\u524d\uff0c\u4e00\u5b9a\u4f1a\u6709\u4eba\u641e\u6e05\u695a\u4fdd\u9669\u5e93\u7684\u4f5c\u7528\uff0c\"Rome \u8bf4\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u5173\u4e8e AHB \u5b9e\u9a8c\u5ba4<\/h2>\n<p>\u5728 <a href=\"https:\/\/www.ahb-lab.com\/zh\/\">AHB Lab<\/a>\u6211\u4eec\u4e0d\u4ec5\u662f\u591a\u80bd\u5408\u6210\u9886\u57df\u7684\u9886\u5bfc\u8005\uff0c\u6211\u4eec\u8fd8\u662f\u751f\u7269\u6280\u672f\u63a2\u7d22\u5148\u950b\u7684\u6838\u5fc3\u3002\u6211\u4eec\u7684\u5173\u6ce8\u70b9\u4e0d\u4ec5\u4ec5\u5c40\u9650\u4e8e\u591a\u80bd\u7684\u751f\u4ea7\uff0c\u8fd8\u4f53\u73b0\u4e86\u63a8\u52a8\u6574\u4e2a\u751f\u7269\u6280\u672f\u9886\u57df\u521b\u65b0\u7684\u613f\u666f\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u63a2\u7d22\u591a\u80bd\u7ed3\u6784\u548c\u529f\u80fd\u7684\u5965\u79d8\uff0c\u63ed\u5f00\u5206\u5b50\u5965\u79d8\u7684\u795e\u79d8\u9762\u7eb1\uff0c\u4ece\u800c\u627e\u5230\u7a81\u7834\u6027\u7684\u5065\u5eb7\u89e3\u51b3\u65b9\u6848\u3002\u901a\u8fc7\u4e0e\u6700\u65b0\u7684\u79d1\u5b66\u7814\u7a76\u548c\u6280\u672f\u8fdb\u6b65\u4fdd\u6301\u4e00\u81f4\uff0cAHB 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Tanaka\u3001K. Kato \u7b49\u4eba\u6839\u636e CC BY-SA 3.0 \u4f7f\u7528\u3002<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>The Discovery of Vaults Leonard Rome switches off the overhead light in a small room, leaving it illuminated only by a computer monitor and the fluorescent screen at the base of a towering electron microscope. Qing Lou, a Ph.D. student at the University of California, Los Angeles (UCLA), points to some ovoid smudges within the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1967,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-1961","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Biologist Aims to Solve Cell&#039;s Biggest Mystery: Vaults - AHB Lab<\/title>\n<meta name=\"description\" content=\"Biologist Leonard Rome aims to solve the mystery of cellular vaults, potentially unlocking new cancer therapies. 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