{"id":2342,"date":"2024-07-10T02:27:13","date_gmt":"2024-07-10T02:27:13","guid":{"rendered":"https:\/\/www.ahb-lab.com\/?p=2342"},"modified":"2024-07-10T02:27:13","modified_gmt":"2024-07-10T02:27:13","slug":"is-mimicking-hemoglobin-cells-the-key-to-a-blood-substitute","status":"publish","type":"post","link":"https:\/\/www.ahb-lab.com\/zh\/news\/is-mimicking-hemoglobin-cells-the-key-to-a-blood-substitute\/","title":{"rendered":"\u6a21\u4eff\u8840\u7ea2\u86cb\u767d\u7ec6\u80de\u662f\u8840\u6db2\u66ff\u4ee3\u54c1\u7684\u5173\u952e\u5417\uff1f"},"content":{"rendered":"<h2>\u5bfc\u8a00\uff1a\u5bfb\u627e\u8840\u6db2\u66ff\u4ee3\u54c1<\/h2>\n<p>19 \u4e16\u7eaa\uff0c\u7ebd\u7ea6\u5e02\u8457\u540d\u5987\u79d1\u533b\u751f\u897f\u5965\u591a-\u76d6\u62c9\u5fb7-\u6258\u9a6c\u65af\u63d0\u51fa\u4e86\u4e00\u4e2a\u4e0d\u540c\u5bfb\u5e38\u7684\u60f3\u6cd5\uff1a\u7528\u725b\u5976\u4ee3\u66ff\u8840\u6db2\u3002\u5c3d\u7ba1\u6700\u521d\u8fdb\u884c\u4e86\u4e00\u4e9b\u8bd5\u9a8c\uff0c\u5305\u62ec\u5411\u4e00\u540d\u4e25\u91cd\u5b50\u5bab\u51fa\u8840\u7684\u75c5\u4eba\u6ce8\u5c04\u725b\u5976\uff0c\u4f46\u7531\u4e8e\u5176\u98ce\u9669\u548c\u5e76\u53d1\u75c7\uff0c\u8fd9\u79cd\u505a\u6cd5\u6619\u82b1\u4e00\u73b0\u3002\u7136\u800c\uff0c\u4eba\u4eec\u4e00\u76f4\u5728\u5bfb\u627e\u4e00\u79cd\u66f4\u5b89\u5168\u3001\u66f4\u6709\u6548\u7684\u8840\u6db2\u66ff\u4ee3\u54c1\u3002<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone wp-image-2343 size-full\" src=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/07\/WX20240710-101615@2x.png\" alt=\"blood\" width=\"1944\" height=\"1088\" srcset=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/07\/WX20240710-101615@2x.png 1944w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/07\/WX20240710-101615@2x-300x168.png 300w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/07\/WX20240710-101615@2x-1024x573.png 1024w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/07\/WX20240710-101615@2x-768x430.png 768w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/07\/WX20240710-101615@2x-1536x860.png 1536w, https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2024\/07\/WX20240710-101615@2x-18x10.png 18w\" sizes=\"(max-width: 1944px) 100vw, 1944px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h2>\u65e9\u671f\u5c1d\u8bd5\u548c\u521b\u65b0\u7684\u5fc5\u8981\u6027<\/h2>\n<p>19 \u4e16\u7eaa\u672b\uff0c\u7531\u4e8e\u7f3a\u4e4f\u5bf9\u8840\u578b\u7684\u4e86\u89e3\uff0c\u8f93\u8840\u662f\u4e00\u9879\u9ad8\u98ce\u9669\u7684\u5de5\u4f5c\u3002\u8fd9\u5f80\u5f80\u4f1a\u5bfc\u81f4\u6eb6\u8840\u6027\u4f11\u514b\uff0c\u5373\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\u8f93\u8840\u7ec6\u80de\u3002\u4e3a\u4e86\u5bfb\u6c42\u4e00\u79cd\u5371\u9669\u6027\u8f83\u4f4e\u7684\u66ff\u4ee3\u65b9\u6cd5\uff0c\u533b\u751f\u4eec\u5c1d\u8bd5\u4e86\u5305\u62ec\u725b\u5976\u5728\u5185\u7684\u5404\u79cd\u7269\u8d28\uff0c\u4f46\u8fd9\u4e9b\u52aa\u529b\u5f88\u5feb\u5c31\u88ab\u4f5c\u4e3a\u4e34\u65f6\u63aa\u65bd\u7684\u751f\u7406\u76d0\u6c34\u6240\u53d6\u4ee3\u3002<\/p>\n<p>\u5bf9\u53ef\u9760\u8840\u6db2\u66ff\u4ee3\u54c1\u7684\u9700\u6c42\u4ecd\u7136\u81f3\u5173\u91cd\u8981\u3002\u4e25\u91cd\u5931\u8840\u5bfc\u81f4\u7684\u5931\u8840\u6027\u4f11\u514b\u6bcf\u5e74\u5728\u7f8e\u56fd\u593a\u8d70\u7ea6 2 \u4e07\u4eba\u7684\u751f\u547d\uff0c\u5728\u5168\u7403\u593a\u8d70 200 \u4e07\u4eba\u7684\u751f\u547d\u3002\u732e\u8840\u7684\u5c40\u9650\u6027\u5305\u62ec\u4fdd\u8d28\u671f\u53ea\u6709 42 \u5929\uff0c\u4f9b\u5e94\u4e0d\u8db3\uff0c\u5c24\u5176\u662f\u666e\u904d\u7684 O \u578b\u9634\u6027\u732e\u8840\u8005\uff0c\u8fd9\u51f8\u663e\u4e86\u5bfb\u627e\u66ff\u4ee3\u54c1\u7684\u7d27\u8feb\u6027\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>ErythroMer\uff1a\u65b0\u5e0c\u671b<\/h2>\n<p>\u5728\u5df4\u5c14\u7684\u6469\u7684\u4e00\u4e2a\u5b9e\u9a8c\u5ba4\u91cc\uff0c\u4e00\u53ea\u767d\u8272\u7684\u5154\u5b50\u4ee3\u8868\u7740\u8840\u6db2\u66ff\u4ee3\u54c1\u7684\u6700\u65b0\u5e0c\u671b\u3002 <a href=\"https:\/\/kalocyte.com\/erythromer\/\">ErythroMer<\/a>ErythroMer \u662f\u7531\u9a6c\u91cc\u5170\u5927\u5b66\u533b\u5b66\u9662\u7684 Allan Doctor \u535a\u58eb\u53ca\u5176\u56e2\u961f\u5f00\u53d1\u7684\u4e00\u79cd\u5b9e\u9a8c\u6027\u8840\u6db2\u66ff\u4ee3\u54c1\uff0c\u7531\u56de\u6536\u7684\u4eba\u7c7b\u8840\u7ea2\u86cb\u767d\u5236\u6210\u3002ErythroMer \u88ab\u5c01\u88c5\u5728\u8584\u819c\u4e2d\u4ee5\u6a21\u4eff\u5fae\u5c0f\u7684\u7ec6\u80de\uff0c\u5728\u52a8\u7269\u8bd5\u9a8c\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u6548\u679c\uff0c\u80fd\u4fdd\u6301\u7a33\u5b9a\u7684\u5fc3\u7387\u548c\u8840\u538b\u3002<\/p>\n<p>\u535a\u58eb\u63d0\u5021\u4f7f\u7528\u8840\u7ea2\u86cb\u767d\u6c27\u8f7d\u4f53\uff08HBOC\uff09\uff0c\u5982 ErythroMer\u3002\u8fd9\u79cd\u66ff\u4ee3\u54c1\u53ef\u5728\u8d27\u67b6\u4e0a\u4fdd\u5b58\u6570\u5e74\uff0c\u53ef\u7528\u751f\u7406\u76d0\u6c34\u91cd\u65b0\u914d\u5236\uff0c\u7531\u4e8e\u4e0d\u542b\u5bfc\u81f4\u4e0d\u5339\u914d\u7684\u7ea2\u7ec6\u80de\u8868\u9762\u86cb\u767d\uff0c\u56e0\u6b64\u5177\u6709\u666e\u904d\u517c\u5bb9\u6027\u3002\u5728\u7d27\u6025\u60c5\u51b5\u4e0b\uff0c\u4f8b\u5982\u5728\u6218\u573a\u6216\u6551\u62a4\u8f66\u7b49\u5f85\u65f6\u95f4\u8f83\u957f\u7684\u519c\u6751\u5730\u533a\uff0cErythroMer \u53ef\u4ee5\u5728\u75c5\u4eba\u5230\u8fbe\u533b\u9662\u4e4b\u524d\u63d0\u4f9b\u91cd\u8981\u7684\u6865\u6881\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u5f00\u53d1\u8840\u6db2\u66ff\u4ee3\u54c1\u7684\u6311\u6218<\/h2>\n<p>\u8840\u6db2\u66ff\u4ee3\u54c1\u7684\u5f00\u53d1\u9762\u4e34\u7740\u91cd\u5927\u6311\u6218\u3002\u65e9\u671f\u7684 HBOC \u4f7f\u7528\u65e0\u819c\u7684\u6e38\u79bb\u8840\u7ea2\u86cb\u767d\uff0c\u5177\u6709\u6bd2\u6027\uff0c\u4f1a\u5f15\u8d77\u4e25\u91cd\u7684\u526f\u4f5c\u7528\uff0c\u5982\u9ad8\u8840\u538b\u548c\u5fc3\u810f\u75c5\u53d1\u4f5c\u3002\u8fd9\u662f\u7531\u4e8e\u8840\u7ea2\u86cb\u767d\u4e0e\u4e00\u6c27\u5316\u6c2e\uff08\u4e00\u79cd\u6709\u52a9\u4e8e\u6269\u5f20\u8840\u7ba1\u7684\u6c14\u4f53\uff09\u76f8\u4e92\u4f5c\u7528\u6240\u81f4\u3002\u672a\u5c01\u88c5\u7684\u8840\u7ea2\u86cb\u767d\u5f80\u5f80\u4f1a\u6e05\u9664\u8fc7\u591a\u7684\u4e00\u6c27\u5316\u6c2e\uff0c\u5bfc\u81f4\u5371\u9669\u7684\u8840\u7ba1\u6536\u7f29\u3002<\/p>\n<p>DARPA \u9879\u76ee\u65e8\u5728\u901a\u8fc7\u5f00\u53d1\u5408\u6210\u8840\u6db2\u6210\u5206\uff08\u5305\u62ec ErythroMer\u3001\u5408\u6210\u8840\u5c0f\u677f\u548c\u51bb\u5e72\u8840\u6d46\uff09\u6765\u514b\u670d\u8fd9\u4e9b\u969c\u788d\u3002ErythroMer \u7684\u8bbe\u8ba1\u975e\u5e38\u63a5\u8fd1\u5929\u7136\u7ea2\u7ec6\u80de\uff0c\u5176\u7cbe\u5bc6\u7684\u819c\u53ef\u4ee5\u8c03\u8282\u6c27\u6c14\u7684\u6355\u83b7\u548c\u91ca\u653e\uff0c\u4ece\u800c\u907f\u514d\u4e86\u65e9\u671f HBOCs \u7684\u6bd2\u6027\u95ee\u9898\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u672a\u6765\u4e4b\u8def<\/h2>\n<p>ErythroMer \u4ecd\u5728\u8fdb\u884c\u52a8\u7269\u8bd5\u9a8c\uff0c\u4f46\u5176\u6f5c\u529b\u5df2\u5f15\u8d77\u4e86\u4eba\u4eec\u7684\u6781\u5927\u5174\u8da3\uff0c\u5e76\u83b7\u5f97\u4e86\u5927\u91cf\u8d44\u91d1\uff0c\u5305\u62ec\u7f8e\u56fd\u56fd\u9632\u90e8\u9ad8\u7ea7\u7814\u7a76\u8ba1\u5212\u5c40\uff08DARPA\uff09\u4e3a\u8fdb\u4e00\u6b65\u5f00\u53d1 ErythroMer \u63d0\u4f9b\u7684 $46 \u767e\u4e07\u7f8e\u5143\u8d44\u52a9\u3002<\/p>\n<p>\u5c06\u8840\u7ea2\u86cb\u767d\u5305\u88f9\u5728\u8102\u8d28\u4e2d\u7684\u5176\u4ed6\u5de5\u4f5c\u4e5f\u5728\u8fdb\u884c\u4e2d\u3002\u5728\u65e5\u672c\uff0c\u5316\u5b66\u5bb6 Hiromi Sakai \u9886\u5bfc\u7684\u56e2\u961f\u6b63\u5728\u5f00\u53d1\u8840\u7ea2\u86cb\u767d\u56ca\u6ce1 (HbVs)\uff0c\u5728\u4eba\u4f53\u8bd5\u9a8c\u4e2d\u663e\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u521d\u6b65\u5b89\u5168\u6027\u7ed3\u679c\u3002\u540c\u6837\uff0cHemarina \u7b49\u516c\u53f8\u4e5f\u5728\u63a2\u7d22\u72ec\u7279\u7684\u65b9\u6cd5\uff0c\u5982\u5229\u7528\u6d77\u6d0b\u8815\u866b\u7684\u6e38\u79bb\u8840\u7ea2\u86cb\u767d\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u514b\u670d\u6000\u7591\uff0c\u52c7\u5f80\u76f4\u524d<\/h2>\n<p>\u901a\u5f80\u53ef\u884c\u7684\u8840\u6db2\u66ff\u4ee3\u54c1\u4e4b\u8def\u5145\u6ee1\u632b\u6298\u3002\u4ee5\u524d\u7684 HBOC \u56e0\u5176\u526f\u4f5c\u7528\u800c\u9971\u53d7\u6279\u8bc4\uff0c\u5bfc\u81f4\u8bd5\u9a8c\u4e2d\u6b62\u548c\u7834\u4ea7\u3002Hemopure \u662f\u4e00\u79cd\u63d0\u53d6\u81ea\u725b\u8840\u7ea2\u86cb\u767d\u7684 HBOC\uff0c2008 \u5e74\u7684\u4e00\u9879\u835f\u8403\u5206\u6790\u5f15\u8d77\u4e86\u4eba\u4eec\u5bf9\u5176\u5b89\u5168\u6027\u7684\u62c5\u5fe7\uff0c\u6b64\u540e\uff0cHemopure \u9762\u4e34\u7740\u5de8\u5927\u7684\u969c\u788d\u3002\u7136\u800c\uff0c\u4e00\u4e9b\u533b\u7597\u4e13\u4e1a\u4eba\u58eb\u4ecd\u5728\u7279\u5b9a\u60c5\u51b5\u4e0b\u4f7f\u7528 Hemopure\uff0c\u4f8b\u5982\u7528\u4e8e\u56e0\u5b97\u6559\u539f\u56e0\u62d2\u7edd\u8f93\u8840\u7684\u75c5\u4eba\u3002<\/p>\n<p>\u535a\u58eb\u548c\u4ed6\u7684\u56e2\u961f\u4ecd\u7136\u770b\u597d ErythroMer \u7684\u6f5c\u529b\u3002\u4ed6\u4eec\u5e0c\u671b\u901a\u8fc7\u5bc6\u5207\u6a21\u4eff\u7ea2\u7ec6\u80de\u7684\u5929\u7136\u529f\u80fd\u5e76\u5c06\u8840\u7ea2\u86cb\u767d\u5c01\u88c5\u5728\u4fdd\u62a4\u819c\u5185\uff0c\u907f\u514d\u8fc7\u53bb\u7684\u7f3a\u9677\uff0c\u5e76\u63d0\u4f9b\u4e00\u79cd\u5b89\u5168\u3001\u6709\u6548\u7684\u732e\u8840\u66ff\u4ee3\u54c1\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u7ed3\u8bba\uff1a\u8840\u6db2\u66ff\u4ee3\u54c1\u7684\u672a\u6765<\/h2>\n<p>\u5f00\u53d1\u53ef\u9760\u7684\u8840\u6db2\u66ff\u4ee3\u54c1\u662f\u4e00\u9879\u6301\u7eed\u7684\u6311\u6218\uff0c\u4f46\u9700\u6c42\u662f\u4e0d\u53ef\u5426\u8ba4\u7684\u3002\u968f\u7740\u7814\u7a76\u7684\u4e0d\u65ad\u6df1\u5165\u548c\u8d44\u91d1\u7684\u6301\u7eed\u6295\u5165\uff0c\u50cf ErythroMer \u8fd9\u6837\u7684\u521b\u65b0\u4ea7\u54c1\u5c06\u5f7b\u5e95\u6539\u53d8\u6025\u8bca\u533b\u5b66\uff0c\u4e3a\u4e25\u91cd\u5931\u8840\u63d0\u4f9b\u4e00\u79cd\u7a33\u5b9a\u3001\u901a\u7528\u7684\u89e3\u51b3\u65b9\u6848\u3002\u5728\u79d1\u5b66\u754c\u7684\u63a8\u52a8\u4e0b\uff0c\u5b89\u5168\u3001\u6709\u6548\u7684\u8840\u6db2\u66ff\u4ee3\u54c1\u7684\u68a6\u60f3\u53ef\u80fd\u5f88\u5feb\u5c31\u4f1a\u6210\u4e3a\u73b0\u5b9e\uff0c\u5e76\u5728\u6b64\u8fc7\u7a0b\u4e2d\u633d\u6551\u65e0\u6570\u751f\u547d\u3002<\/p>\n<p>\u5728<a href=\"https:\/\/www.ahb-lab.com\/zh\/\"> AHB Lab<\/a>\u6211\u4eec\u4e0d\u4ec5\u662f\u591a\u80bd\u5408\u6210\u9886\u57df\u7684\u9886\u5bfc\u8005\uff0c\u6211\u4eec\u8fd8\u662f\u751f\u7269\u6280\u672f\u63a2\u7d22\u5148\u950b\u7684\u6838\u5fc3\u3002\u6211\u4eec\u7684\u627f\u8bfa\u4e0d\u4ec5\u9650\u4e8e\u638c\u63e1\u591a\u80bd\u751f\u4ea7\u6280\u672f\uff0c\u8fd8\u81f4\u529b\u4e8e\u63a8\u52a8\u6574\u4e2a\u751f\u7269\u6280\u672f\u9886\u57df\u7684\u521b\u65b0\u3002\u901a\u8fc7\u4e0e\u6700\u65b0\u7684\u79d1\u5b66\u7814\u7a76\u548c\u6280\u672f\u8fdb\u6b65\u4fdd\u6301\u4e00\u81f4\uff0c\u6211\u4eec\u81f4\u529b\u4e8e\u5f15\u9886\u53d1\u5c55\uff0c\u52a0\u6df1\u6211\u4eec\u5bf9\u591a\u80bd\u7684\u7406\u89e3\uff0c\u4e3a\u9769\u547d\u6027\u7684\u751f\u7269\u6280\u672f\u5e94\u7528\u94fa\u5e73\u9053\u8def\u3002\u5728\u62a5\u9053 ErythroMer \u7b49\u7a81\u7834\u6027\u8fdb\u5c55\u65f6\uff0c\u6211\u4eec\u5f3a\u8c03\u4e86\u81ea\u5df1\u5728\u5851\u9020\u751f\u7269\u6280\u672f\u672a\u6765\u4e2d\u7684\u4f5c\u7528\uff0c\u5e76\u4e3a\u6025\u8bca\u533b\u5b66\u53ca\u5176\u4ed6\u9886\u57df\u7684\u9769\u547d\u6027\u89e3\u51b3\u65b9\u6848\u505a\u51fa\u4e86\u8d21\u732e\u3002\u52a0\u5165\u6211\u4eec\u7684\u63a2\u7d22\u884c\u5217\uff0c\u6211\u4eec\u5c06\u575a\u5b9a\u4e0d\u79fb\u5730\u8ffd\u6c42\u5353\u8d8a\u548c\u521b\u65b0\uff0c\u4e3a\u79d1\u5b66\u5f00\u8f9f\u65b0\u7684\u9053\u8def\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>Introduction: The Quest for a Blood Substitute In the 19th century, Theodore Gaillard Thomas, a renowned gynecologist in New York City, championed an unusual idea: transfusing milk as a substitute for blood. Despite initial trials, including one where cow\u2019s milk was injected into a patient with severe uterine bleeding, the practice was short-lived due to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2346,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-2342","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Is Mimicking Hemoglobin Cells the Key to a Blood Substitute? - AHB Lab<\/title>\n<meta name=\"description\" content=\"ErythroMer: a new blood substitute mimicking hemoglobin cells, promising a universal, stable solution for emergency medicine.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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