{"id":3260,"date":"2025-01-17T04:44:22","date_gmt":"2025-01-17T04:44:22","guid":{"rendered":"https:\/\/www.ahb-lab.com\/?p=3260"},"modified":"2025-01-17T04:44:22","modified_gmt":"2025-01-17T04:44:22","slug":"a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression","status":"publish","type":"post","link":"https:\/\/www.ahb-lab.com\/zh\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/","title":{"rendered":"\u8166\u7d30\u80de\u4e2d\u300c\u6ef4\u7b54\u4f5c\u54cd\u7684 DNA \u9418\u300d\u9a45\u52d5\u4ea8\u5ef7\u9813\u6c0f\u75c7\u60e1\u5316"},"content":{"rendered":"<h2>\u77ad\u89e3\u4ea8\u5ef7\u9813\u75c7\u7684\u907a\u50b3\u5143\u51f6<\/h2>\n<p>\u4e09\u5341\u591a\u5e74\u4f86\uff0c\u6709\u7f3a\u9677\u7684 HTT \u57fa\u56e0\u4e00\u76f4\u88ab\u79d1\u5b78\u5bb6\u6b78\u548e\u70ba\u4ea8\u5ef7\u9813\u6c0f\u75c7\u7684\u539f\u56e0\u3002 <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/huntingtons-disease\/symptoms-causes\/syc-20356117\">\u75be\u75c5\u3001<\/a> \u662f\u4e00\u7a2e\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff0c\u6703\u9010\u6f38\u7834\u58de\u8166\u7d30\u80de\u3002\u9019\u7a2e\u907a\u50b3\u7f3a\u9677\u6703\u9020\u6210\u4ee4\u4eba\u8870\u5f31\u7684\u75c7\u72c0\uff0c\u4f8b\u5982\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\u3001\u5fc3\u7406\u554f\u984c\u548c\u52d5\u4f5c\u5931\u63a7\u3002\u4f46\u6709\u4e00\u4ef6\u4e8b\u4e00\u76f4\u4e0d\u70ba\u4eba\u6240\u4e86\u89e3\uff0c\u90a3\u5c31\u662f\u9019\u7a2e\u75be\u75c5\u767c\u75c5\u8f03\u9072\u7684\u539f\u56e0\u3002<\/p>\n<p>\u4e00\u9805\u767c\u8868\u5728\u300a\u7d30\u80de\u300b\uff08Cell\uff09\u671f\u520a\u4e0a\u7684\u65b0\u7814\u7a76\u5831\u544a\u6307\u51fa\uff0c\u8166\u7d30\u80de\u4e2d\u4e0d\u65b7\u64f4\u5927\u7684 DNA \u5728\u75be\u75c5\u9032\u7a0b\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272\u3002\u9019\u4e9b\u767c\u73fe\u53ef\u4ee5\u89e3\u91cb\u70ba\u4ec0\u9ebc\u75c7\u72c0\u51fa\u73fe\u7684\u6642\u9593\u6703\u6bd4\u8f03\u665a\uff0c\u4e5f\u53ef\u4ee5\u89e3\u91cb\u70ba\u4ec0\u9ebc\u9019\u7a2e\u75be\u75c5\u5728\u4e0d\u540c\u7684\u4eba\u8eab\u4e0a\u6709\u4e0d\u540c\u7684\u9032\u5c55\u901f\u5ea6\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u4ea8\u5ef7\u9813\u75c7\u80cc\u5f8c\u7684\u907a\u50b3\u6a5f\u5236<\/h2>\n<p>\u4ea8\u5ef7\u9813\u6c0f\u75c5\u60a3\u8005\u907a\u50b3\u4e86\u6709\u554f\u984c\u7684 HTT \u57fa\u56e0\uff0c\u800c HTT \u57fa\u56e0\u662f\u4ea8\u5ef7\u5ef7\u86cb\u767d\u7684\u4ee3\u78bc\u3002\u8a72\u57fa\u56e0\u6709\u4e09\u500b DNA \u6838\u82f7\u9178\u78b1\u57fa\u7684\u91cd\u8907\u6a21\u5f0f - \u80de\u5627\u5576\u3001\u817a\u560c\u5464\u548c\u9e1f\u560c\u5464\uff0c\u6216\u7a31 CAG - \u9023\u7e8c\u91cd\u8907\u3002\u5927\u591a\u6578\u4eba\u7684 CAG \u91cd\u8986\u6578\u70ba 15-30 \u500b\uff0c\u4f46\u5f9e\u672a\u7f79\u60a3\u4ea8\u5ef7\u9813\u6c0f\u75c7\uff0c\u800c\u91cd\u8986\u6578\u70ba 40 \u500b\u6216\u4ee5\u4e0a\u7684\u4eba\u5e7e\u4e4e\u90fd\u6703\u5728\u665a\u5e74\u51fa\u73fe\u75c7\u72c0\u3002<\/p>\n<p>\u9019\u7a2e\u907a\u50b3\u6027\u53e3\u5403\u6703\u5c0e\u81f4\u4ea8\u5ef7\u86cb\u767d\u8b8a\u5f97\u7570\u5e38\u9f90\u5927\u4e14\u4e0d\u7a69\u5b9a\uff0c\u9019\u4e9b\u86cb\u767d\u6703\u5728\u8166\u7d30\u80de\u5167\u7a4d\u805a\u6210\u584a\u3002\u96a8\u8457\u6642\u9593\u7684\u63a8\u79fb\uff0c\u9019\u6703\u5c0e\u81f4\u795e\u7d93\u5143\u6b7b\u4ea1\uff0c\u5c24\u5176\u662f\u5728\u5f71\u97ff\u52d5\u4f5c\u548c\u52d5\u6a5f\u7684\u5927\u8166\u90e8\u5206--\u7d0b\u72c0\u9ad4\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u96b1\u85cf\u7684\u904e\u7a0b\uff1a\u9ad4\u8cea\u64f4\u5f35<\/h2>\n<p>\u76f4\u5230\u6700\u8fd1\uff0c\u79d1\u5b78\u754c\u9084\u8a8d\u70ba\u4e00\u500b\u4eba\u7684 CAG \u91cd\u8907\u6b21\u6578\u5b8c\u5168\u662f\u907a\u50b3\u6240\u81f4\u3002\u7136\u800c\u5728 2003 \u5e74\uff0c\u4e00\u500b\u4ee4\u4eba\u9a5a\u8a1d\u7684\u73fe\u8c61\u51fa\u73fe\u4e86\uff0cCAG \u91cd\u8907\u5e8f\u5217\u7684\u6578\u91cf\u5728\u4eba\u7684\u4e00\u751f\u4e2d\u6703\u4e0d\u65b7\u589e\u52a0\uff0c\u5c24\u5176\u662f\u5728\u8166\u7d30\u80de\u4e2d\u3002\u9019\u500b\u904e\u7a0b\u88ab\u7a31\u70ba\u9ad4\u5167\u64f4\u589e\uff0c\u5728\u8166\u7d0b\u4e2d\u5c24\u5176\u660e\u986f\uff0c\u6709\u4e9b\u7d30\u80de\u7d2f\u7a4d\u4e86\u591a\u9054 1000 \u500b\u91cd\u8986\u6b21\u6578\uff0c\u9060\u8d85\u904e\u51fa\u751f\u6642\u7684\u6578\u91cf\u3002<\/p>\n<p>\u591a\u5e74\u4f86\uff0c\u9ad4\u8cea\u64f4\u6563\u5728\u4ea8\u5ef7\u9813\u6c0f\u75c7\u4e2d\u6240\u626e\u6f14\u7684\u89d2\u8272\u4e26\u4e0d\u660e\u78ba\u3002\u8a31\u591a\u7814\u7a76\u4eba\u54e1\u8a8d\u70ba\uff0c\u9577\u671f\u66b4\u9732\u65bc\u7a81\u8b8a\u7684\u4ea8\u5ef7\u9813\u86cb\u767d\u8cea\u6703\u5c0e\u81f4\u795e\u7d93\u5143\u9010\u6f38\u6b7b\u4ea1\u3002\u7136\u800c\uff0c\u6700\u8fd1\u7684\u767c\u73fe\u537b\u8207\u6b64\u4e0d\u540c\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>DNA \u8a08\u6642\u9418 \"\u7684\u4f5c\u7528<\/h2>\n<p>\u70ba\u4e86\u66f4\u4e86\u89e3\u9ad4\u8cea\u64f4\u589e\u8207\u4ea8\u5ef7\u9813\u75c7\u4e4b\u9593\u7684\u95dc\u4fc2\uff0c\u7814\u7a76\u4eba\u54e1\u89c0\u5bdf\u4e86 103 \u4f4d\u6350\u8d08\u8005\u7684\u8166\u7d44\u7e54\uff0c\u5176\u4e2d\u5305\u62ec\u4ea8\u5ef7\u9813\u75c7\u60a3\u8005\u548c\u975e\u4ea8\u5ef7\u9813\u75c7\u60a3\u8005\u3002\u7814\u7a76\u5718\u968a\u4f7f\u7528\u96fb\u8166\u5efa\u6a21\u548c RNA \u5206\u6790\uff0c\u8ffd\u8e64\u8d85\u904e 50 \u842c\u500b\u55ae\u7d30\u80de\u7684\u57fa\u56e0\u8b8a\u5316\u3002<\/p>\n<p>\u4ed6\u5011\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u53d7\u4ea8\u5ef7\u9813\u75c7\u5f71\u97ff\u7684\u795e\u7d93\u5143\u6709\u975e\u5e38\u4e0d\u5c0b\u5e38\u7684\u767c\u5c55\u904e\u7a0b\u3002\u5927\u7d04\u4e8c\u5341\u5e74\u4f86\uff0cHTT \u57fa\u56e0\u4e2d\u7684 CAG \u91cd\u8907\u5e8f\u5217\u64f4\u5c55\u5f97\u975e\u5e38\u7de9\u6162\u3002\u7136\u800c\uff0c\u4e00\u65e6\u5e8f\u5217\u9577\u5ea6\u9054\u5230\u7d04 80 \u500b\u91cd\u8986\u6b21\u6578\uff0c\u64f4\u5927\u7684\u901f\u5ea6\u5c31\u6703\u986f\u8457\u52a0\u5feb\u3002\u5728\u77ed\u77ed\u5e7e\u5e74\u9593\uff0c\u5e8f\u5217\u901a\u5e38\u6703\u64f4\u5927\u5230 150 \u500b\u91cd\u8986\u6b21\u6578 - \u4e00\u500b\u6709\u6bd2\u7684\u81e8\u754c\u503c\uff0c\u8d85\u904e\u9019\u500b\u81e8\u754c\u503c\uff0c\u795e\u7d93\u5143\u5c31\u6703\u9000\u5316\uff0c\u4e26\u5728\u5e7e\u500b\u6708\u5167\u6b7b\u4ea1\u3002\u9019\u7a2e\u985e\u578b\u7684\u9032\u5c55\u88ab\u6bd4\u55bb\u70ba\u300c\u6ef4\u7b54\u4f5c\u97ff\u7684 DNA \u6642\u9418\u300d\uff1a\u4e00\u65e6\u6642\u9418\u8017\u76e1\uff0c\u795e\u7d93\u5143\u5c31\u6703\u6b7b\u4ea1\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u89e3\u91cb\u5ef6\u9072\u767c\u75c5\u548c\u591a\u8b8a\u7684\u9032\u7a0b<\/h2>\n<p>\u4ea8\u5ef7\u9813\u6c0f\u75c7\u7684\u53e6\u4e00\u500b\u555f\u793a\u4f86\u81ea\u300c\u6ef4\u7b54\u4f5c\u97ff\u7684 DNA \u6642\u9418\u300d\u3002\u7531\u65bc\u64f4\u589e\u904e\u7a0b\u9700\u8981\u6578\u5341\u5e74\u624d\u80fd\u5728\u8db3\u5920\u7684\u795e\u7d93\u5143\u4e2d\u9054\u5230\u81e8\u754c\u503c\uff0c\u56e0\u6b64\u75c7\u72c0\u6703\u5728\u4e2d\u5e74\u6642\u51fa\u73fe\u3002\u91cd\u8907\u5e8f\u5217\u7d2f\u7a4d\u901f\u5ea6\u7684\u8b8a\u5316\u4e5f\u89e3\u91cb\u4e86\u70ba\u4ec0\u9ebc\u6bcf\u500b\u4eba\u7684\u75c5\u60c5\u9032\u5c55\u90fd\u4e0d\u540c\u3002<\/p>\n<p>\u9019\u7a2e\u6a6b\u7a81\u9762\u7684\u62fc\u6e4a\u5f0f\u640d\u50b7\u8207\u4ea8\u5ef7\u9813\u75c5\u60a3\u7684\u5404\u7a2e\u75c7\u72c0\u76f8\u7b26\u3002\u6709\u4e9b\u795e\u7d93\u5143\u6703\u5148\u65bc\u5176\u4ed6\u795e\u7d93\u5143\u8de8\u904e\u6bd2\u6027\u81e8\u754c\u503c\uff0c\u56e0\u6b64\u75be\u75c5\u7684\u56b4\u91cd\u6027\u548c\u60e1\u5316\u6642\u9593\u6703\u6709\u986f\u8457\u7684\u5dee\u7570\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u6f5b\u5728\u6cbb\u7642\u7b56\u7565<\/h2>\n<p>\u9ad4\u5167\u64f4\u5f35\u4f5c\u7528\u7684\u767c\u73fe\u70ba\u6cbb\u7642\u958b\u95e2\u4e86\u65b0\u7684\u9014\u5f91\u3002\u7814\u7a76\u767c\u73fe\u4e86\u67d0\u4e9b\u53c3\u8207\u64f4\u589e\u904e\u7a0b\u7684\u9175\u7d20\u3002\u9019\u4e9b\u9175\u7d20\u901a\u5e38\u6703\u53c3\u8207\u4fee\u5fa9 DNA \u932f\u8aa4\uff0c\u4f46\u6709\u6642\u4e5f\u6703\u51fa\u932f\uff0c\u63d2\u5165\u984d\u5916\u7684 CAG \u91cd\u8907\u5e8f\u5217\u3002\u7406\u8ad6\u4e0a\uff0c\u91dd\u5c0d\u9019\u4e9b\u9175\u7d20\u53ef\u4ee5\u6e1b\u7de9\u6216\u9632\u6b62\u9ad4\u8cea\u64f4\u6563\uff0c\u4e26\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6709\u5e0c\u671b\u66ff\u4ee3\u73fe\u6709\u65e8\u5728\u6d88\u9664\u7a81\u8b8a\u4ea8\u5ef7\u86cb\u767d\u7684\u7642\u6cd5\u3002<\/p>\n<h3>\u9175\u7d20\u6291\u5236\u7642\u6cd5<\/h3>\n<p>\u5176\u4e2d\u4e00\u500b\u5f88\u6709\u5e0c\u671b\u7684\u6cbb\u7642\u76ee\u6a19\u662f MSH3\uff0c\u5b83\u662f\u4e00\u7a2e\u53c3\u8207\u9ad4\u8cea\u64f4\u589e\u904e\u7a0b\u7684\u9175\u7d20\u3002\u7814\u7a76\u4eba\u54e1\u6b63\u5728\u7814\u7a76\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u6291\u5236 MSH3\uff0c\u4ee5\u963b\u6b62 CAG \u91cd\u8907\u5e8f\u5217\u7684\u6bd2\u6027\u64f4\u589e\u3002\u96d6\u7136\u9019\u4e9b\u6cbb\u7642\u4ecd\u8655\u65bc\u65e9\u671f\u968e\u6bb5\uff0c\u4f46\u6709\u671d\u4e00\u65e5\u53ef\u80fd\u6703\u70ba\u6709\u75c7\u72c0\u7684\u75c5\u60a3\u5e36\u4f86\u5e0c\u671b\u3002<\/p>\n<h3>\u96d9\u91cd\u65b9\u6cd5<\/h3>\n<p>\u7d50\u5408\u91dd\u5c0d\u9ad4\u8cea\u64f4\u6563\u548c\u7a81\u8b8a\u4ea8\u5ef7\u6c40\u86cb\u767d\u7522\u751f\u7684\u7642\u6cd5\uff0c\u53ef\u80fd\u6703\u4f7f\u6cbb\u7642\u6548\u76ca\u6700\u5927\u5316\u3002\u9019\u6a23\u7684\u7b56\u7565\u53ef\u80fd\u6703\u62ef\u6551 95% \u5728\u75be\u75c5\u65e9\u671f\u968e\u6bb5\u672a\u53d7\u5f71\u97ff\u7684\u795e\u7d93\u5143\uff0c\u751a\u81f3\u5728\u75c7\u72c0\u51fa\u73fe\u4e4b\u5f8c\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u9081\u5411\u8a3a\u6240<\/h2>\n<p>\u9019\u9805\u65b0\u7814\u7a76\u6a19\u8a8c\u8457\u4ea8\u5ef7\u9813\u75c5\u7814\u7a76\u7684\u4e00\u5927\u8e8d\u9032\uff0c\u4e26\u9996\u6b21\u532f\u96c6\u4e86\u6578\u5341\u5e74\u4f86\u95dc\u65bc\u9ad4\u8cea\u64f4\u6563\u7684\u8cc7\u8a0a\u3002\u907a\u50b3\u75c5\u57fa\u91d1\u6703 (Hereditary Disease Foundation) \u7684 Sarah Hernandez \u8868\u793a\uff0c\u9019\u6a23\u7684\u767c\u73fe\u70ba\u5275\u65b0\u7642\u6cd5\u6307\u51fa\u4e86\u65b0\u7684\u8def\u5f91\u3002\"\u5979\u8aaa\uff1a\u300c\u9019\u80af\u5b9a\u6703\u5c07\u65b0\u7406\u8ad6\u5e36\u5230\u81e8\u5e8a\u3002<\/p>\n<p>\u96d6\u7136\u6709\u4eba\u6703\u554f\uff0c\u70ba\u4ec0\u9ebc\u9019\u7a2e\u52a0\u901f\u64f4\u5f35\u7684\u73fe\u8c61\u6703\u7279\u5225\u767c\u751f\u5728 80 \u6b21\u91cd\u8907\u4ee5\u4e0a\uff0c\u6216\u7279\u5225\u6d89\u53ca\u5230\u7d0b\u72c0\u9ad4\uff0c\u4f46\u5b83\u537b\u958b\u95e2\u4e86\u4e00\u689d\u901a\u5f80\u6cbb\u7642\u65b9\u6cd5\u7684\u9053\u8def\uff0c\u6709\u671d\u4e00\u65e5\u80fd\u771f\u6b63\u6539\u5584\u4ea8\u5ef7\u9813\u6c0f\u75c7\u60a3\u8005\u7684\u751f\u6d3b\u3002<\/p>\n<p><a href=\"https:\/\/www.ahb-lab.com\/zh\/\">AHB Lab<\/a>\u6211\u5011\u7684\u76ee\u6a19\u662f\u78ba\u4fdd\u60a8\u77ad\u89e3\u79d1\u5b78\u8207\u5275\u65b0\u7684\u6700\u65b0\u767c\u5c55\u3002\u5f9e\u4ea8\u5ef7\u9813\u75c5\u4e2d\u300c\u6ef4\u7b54\u4f5c\u97ff\u7684 DNA \u6642\u9418\u300d\u7684\u7a81\u7834\u6027\u767c\u73fe\uff0c\u5230\u91ab\u5b78\u7684\u9032\u6b65\uff0c\u518d\u5230\u73fe\u4ee3\u79d1\u6280\uff0c\u6211\u5011\u7e3d\u662f\u5617\u8a66\u63d0\u4f9b\u60a8\u76f8\u95dc\u7684\u6700\u65b0\u77e5\u8b58\u3002\u6211\u5011\u975e\u5e38\u6b61\u8fce\u60a8\u8ffd\u8e64\u6211\u5011\u7684\u983b\u9053\uff0c\u4e86\u89e3\u60a8\u8eab\u908a\u7684\u6700\u65b0\u79d1\u5b78\u8cc7\u8a0a\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>Understanding the Genetic Culprit of Huntington Disease For more than three decades, the defective HTT gene has been blamed by scientists for Huntington disease, a neurodegenerative disorder that progressively destroys brain cells. The genetic defect causes debilitating symptoms such as cognitive decline, psychological problems, and uncontrolled movements. But one thing has poorly been understood-the reason [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3261,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,12],"tags":[],"class_list":["post-3260","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-insights","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A \u2018Ticking DNA Clock\u2019 in Brain Cells Drives Huntington Disease Progression - AHB Lab<\/title>\n<meta name=\"description\" content=\"Discover how a &quot;ticking DNA clock&quot; in brain cells drives Huntington disease progression, offering new insights and potential treatment strategies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ahb-lab.com\/zh\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A \u2018Ticking DNA Clock\u2019 in Brain Cells Drives Huntington Disease Progression - AHB Lab\" \/>\n<meta property=\"og:description\" content=\"Discover how a &quot;ticking DNA clock&quot; in brain cells drives Huntington disease progression, offering new insights and potential treatment strategies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ahb-lab.com\/zh\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/\" \/>\n<meta property=\"og:site_name\" content=\"AHB Lab\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-17T04:44:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2025\/01\/AHB-Lab_Blogs-Cover-20250117-01-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1439\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Patrick Wang\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"Patrick Wang\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/\"},\"author\":{\"name\":\"Patrick Wang\",\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/#\\\/schema\\\/person\\\/2647e9bff55b4e1fada671a10a89c013\"},\"headline\":\"A \u2018Ticking DNA Clock\u2019 in Brain Cells Drives Huntington Disease Progression\",\"datePublished\":\"2025-01-17T04:44:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/\"},\"wordCount\":898,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ahb-lab.com\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/AHB-Lab_Blogs-Cover-20250117-01-scaled.jpg\",\"articleSection\":[\"Insights\",\"News\"],\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/\",\"url\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/\",\"name\":\"A \u2018Ticking DNA Clock\u2019 in Brain Cells Drives Huntington Disease Progression - AHB Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ahb-lab.com\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/AHB-Lab_Blogs-Cover-20250117-01-scaled.jpg\",\"datePublished\":\"2025-01-17T04:44:22+00:00\",\"description\":\"Discover how a \\\"ticking DNA clock\\\" in brain cells drives Huntington disease progression, offering new insights and potential treatment strategies.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.ahb-lab.com\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/AHB-Lab_Blogs-Cover-20250117-01-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/www.ahb-lab.com\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/AHB-Lab_Blogs-Cover-20250117-01-scaled.jpg\",\"width\":2560,\"height\":1439,\"caption\":\"cover\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/news\\\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ahb-lab.com\\\/en_us\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A \u2018Ticking DNA Clock\u2019 in Brain Cells Drives Huntington Disease Progression\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/#website\",\"url\":\"https:\\\/\\\/www.ahb-lab.com\\\/\",\"name\":\"AHB Lab\",\"description\":\"Leading Supplier of Biosynthetic Peptide\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ahb-lab.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/#organization\",\"name\":\"AHB Lab\",\"url\":\"https:\\\/\\\/www.ahb-lab.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ahb-lab.com\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/AHB-Lab_Logo-5-20230204.png\",\"contentUrl\":\"https:\\\/\\\/www.ahb-lab.com\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/AHB-Lab_Logo-5-20230204.png\",\"width\":1106,\"height\":281,\"caption\":\"AHB Lab\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.ahb-lab.com\\\/#\\\/schema\\\/person\\\/2647e9bff55b4e1fada671a10a89c013\",\"name\":\"Patrick Wang\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8a3eda228d67d20e915377b9e7439e8be20bf407c4de835f08d069b513900843?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8a3eda228d67d20e915377b9e7439e8be20bf407c4de835f08d069b513900843?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8a3eda228d67d20e915377b9e7439e8be20bf407c4de835f08d069b513900843?s=96&d=mm&r=g\",\"caption\":\"Patrick Wang\"},\"description\":\"Expert of Peptides | Ask me anything about Peptides | Sales Manager at AHB Lab\",\"sameAs\":[\"https:\\\/\\\/www.ahb-lab.com\",\"https:\\\/\\\/www.linkedin.com\\\/in\\\/patrick0228\\\/\"],\"url\":\"https:\\\/\\\/www.ahb-lab.com\\\/zh\\\/author\\\/admin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u8166\u7d30\u80de\u4e2d\u7684\u300cDNA \u8a08\u6642\u9418\u300d\u9a45\u52d5\u4ea8\u5ef7\u9813\u6c0f\u75c7\u9032\u5c55 - AHB Lab","description":"\u767c\u73fe\u5927\u8166\u7d30\u80de\u4e2d\u7684\u300c\u6ef4\u7b54 DNA \u6642\u9418\u300d\u5982\u4f55\u9a45\u4f7f\u4ea8\u5ef7\u9813\u6c0f\u75c7\u60e1\u5316\uff0c\u63d0\u4f9b\u65b0\u7684\u898b\u89e3\u548c\u6f5b\u5728\u7684\u6cbb\u7642\u7b56\u7565\u3002","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ahb-lab.com\/zh\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/","og_locale":"zh_TW","og_type":"article","og_title":"A \u2018Ticking DNA Clock\u2019 in Brain Cells Drives Huntington Disease Progression - AHB Lab","og_description":"Discover how a \"ticking DNA clock\" in brain cells drives Huntington disease progression, offering new insights and potential treatment strategies.","og_url":"https:\/\/www.ahb-lab.com\/zh\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/","og_site_name":"AHB Lab","article_published_time":"2025-01-17T04:44:22+00:00","og_image":[{"width":2560,"height":1439,"url":"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2025\/01\/AHB-Lab_Blogs-Cover-20250117-01-scaled.jpg","type":"image\/jpeg"}],"author":"Patrick Wang","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"Patrick Wang","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"5 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/#article","isPartOf":{"@id":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/"},"author":{"name":"Patrick Wang","@id":"https:\/\/www.ahb-lab.com\/#\/schema\/person\/2647e9bff55b4e1fada671a10a89c013"},"headline":"A \u2018Ticking DNA Clock\u2019 in Brain Cells Drives Huntington Disease Progression","datePublished":"2025-01-17T04:44:22+00:00","mainEntityOfPage":{"@id":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/"},"wordCount":898,"commentCount":0,"publisher":{"@id":"https:\/\/www.ahb-lab.com\/#organization"},"image":{"@id":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/#primaryimage"},"thumbnailUrl":"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2025\/01\/AHB-Lab_Blogs-Cover-20250117-01-scaled.jpg","articleSection":["Insights","News"],"inLanguage":"zh-TW","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/","url":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/","name":"\u8166\u7d30\u80de\u4e2d\u7684\u300cDNA \u8a08\u6642\u9418\u300d\u9a45\u52d5\u4ea8\u5ef7\u9813\u6c0f\u75c7\u9032\u5c55 - AHB Lab","isPartOf":{"@id":"https:\/\/www.ahb-lab.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/#primaryimage"},"image":{"@id":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/#primaryimage"},"thumbnailUrl":"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2025\/01\/AHB-Lab_Blogs-Cover-20250117-01-scaled.jpg","datePublished":"2025-01-17T04:44:22+00:00","description":"\u767c\u73fe\u5927\u8166\u7d30\u80de\u4e2d\u7684\u300c\u6ef4\u7b54 DNA \u6642\u9418\u300d\u5982\u4f55\u9a45\u4f7f\u4ea8\u5ef7\u9813\u6c0f\u75c7\u60e1\u5316\uff0c\u63d0\u4f9b\u65b0\u7684\u898b\u89e3\u548c\u6f5b\u5728\u7684\u6cbb\u7642\u7b56\u7565\u3002","breadcrumb":{"@id":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/#primaryimage","url":"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2025\/01\/AHB-Lab_Blogs-Cover-20250117-01-scaled.jpg","contentUrl":"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2025\/01\/AHB-Lab_Blogs-Cover-20250117-01-scaled.jpg","width":2560,"height":1439,"caption":"cover"},{"@type":"BreadcrumbList","@id":"https:\/\/www.ahb-lab.com\/news\/a-ticking-dna-clock-in-brain-cells-drives-huntington-disease-progression\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.ahb-lab.com\/en_us\/"},{"@type":"ListItem","position":2,"name":"A \u2018Ticking DNA Clock\u2019 in Brain Cells Drives Huntington Disease Progression"}]},{"@type":"WebSite","@id":"https:\/\/www.ahb-lab.com\/#website","url":"https:\/\/www.ahb-lab.com\/","name":"AHB Lab","description":"\u751f\u7269\u5408\u6210\u80bd\u7684\u9886\u5148\u4f9b\u5e94\u5546","publisher":{"@id":"https:\/\/www.ahb-lab.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ahb-lab.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/www.ahb-lab.com\/#organization","name":"AHB Lab","url":"https:\/\/www.ahb-lab.com\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/www.ahb-lab.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/02\/AHB-Lab_Logo-5-20230204.png","contentUrl":"https:\/\/www.ahb-lab.com\/wp-content\/uploads\/2023\/02\/AHB-Lab_Logo-5-20230204.png","width":1106,"height":281,"caption":"AHB Lab"},"image":{"@id":"https:\/\/www.ahb-lab.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.ahb-lab.com\/#\/schema\/person\/2647e9bff55b4e1fada671a10a89c013","name":"Patrick Wang","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/8a3eda228d67d20e915377b9e7439e8be20bf407c4de835f08d069b513900843?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/8a3eda228d67d20e915377b9e7439e8be20bf407c4de835f08d069b513900843?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/8a3eda228d67d20e915377b9e7439e8be20bf407c4de835f08d069b513900843?s=96&d=mm&r=g","caption":"Patrick Wang"},"description":"\u80dc\u80bd\u5c08\u5bb6 \uff5c \u4efb\u4f55\u95dc\u65bc\u80dc\u80bd\u90fd\u53ef\u4ee5\u5411\u6211\u8a62\u554f \uff5c AHB Lab \u570b\u969b\u92b7\u552e\u7d93\u7406","sameAs":["https:\/\/www.ahb-lab.com","https:\/\/www.linkedin.com\/in\/patrick0228\/"],"url":"https:\/\/www.ahb-lab.com\/zh\/author\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/posts\/3260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/comments?post=3260"}],"version-history":[{"count":1,"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/posts\/3260\/revisions"}],"predecessor-version":[{"id":3262,"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/posts\/3260\/revisions\/3262"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/media\/3261"}],"wp:attachment":[{"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/media?parent=3260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/categories?post=3260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ahb-lab.com\/zh\/wp-json\/wp\/v2\/tags?post=3260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}